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Clopidogrel treatment may associate with worsening of endothelial function and development of new digital ulcers in patients with systemic sclerosis: results from an open label, proof of concept study

BACKGROUND: Activated platelets release serotonin that binds 5-HT(2B) receptor on fibroblasts leading to fibroblast activation. Clopidogrel, an inhibitor of ADP-dependent platelet activation prevents fibrosis in animal models of systemic sclerosis (SSc). We aimed at assessing whether i) ADP-dependen...

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Detalles Bibliográficos
Autores principales:	Ntelis, Konstantinos, Gkizas, Vasileios, Filippopoulou, Alexandra, Davlouros, Periclis, Alexopoulos, Dimitrios, Andonopoulos, Andrew P., Daoussis, Dimitrios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869184/ https://www.ncbi.nlm.nih.gov/pubmed/27188755 http://dx.doi.org/10.1186/s12891-016-1072-1

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