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Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways

BACKGROUND: Healing of bone defects is a dynamic and orchestrated process that relies on multiple growth factors and cell types. Bone morphogenetic protein 2 (BMP2) is a key growth factor for bone healing, which stimulates mesenchymal stem cells to differentiate into osteoblasts. Betulinic acid (Bet...

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Detalles Bibliográficos
Autores principales:	Choi, Hyuck, Jeong, Byung-Chul, Kook, Min-Suk, Koh, Jeong-Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869197/ https://www.ncbi.nlm.nih.gov/pubmed/27188281 http://dx.doi.org/10.1186/s12929-016-0260-5

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