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Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase

BACKGROUND: Clozapine, an atypical antipsychotic medication, has been effectively used to treat refractory schizophrenia. However, the clinical usage of clozapine is limited due to a high incidence of neutropenia or agranulocytosis. We previously reported that clozapine protected dopaminergic neuron...

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Detalles Bibliográficos
Autores principales:	Jiang, Lulu, Wu, Xuefei, Wang, Shuo, Chen, Shih-Heng, Zhou, Hui, Wilson, Belinda, Jin, Chun-Yang, Lu, Ru-Band, Xie, Keqin, Wang, Qingshan, Hong, Jau-Shyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869380/ https://www.ncbi.nlm.nih.gov/pubmed/27184631 http://dx.doi.org/10.1186/s12974-016-0573-z

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