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Circulating long non-coding RNAs in cancer: current status and future perspectives
Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869386/ https://www.ncbi.nlm.nih.gov/pubmed/27189224 http://dx.doi.org/10.1186/s12943-016-0524-4 |
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author | Qi, Peng Zhou, Xiao-yan Du, Xiang |
author_facet | Qi, Peng Zhou, Xiao-yan Du, Xiang |
author_sort | Qi, Peng |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studies demonstrating the feasibility of their use as tools in the diagnosis and prognosis of different types of malignancies and for predicting and possibly monitoring treatment response. However, critical issues are represented by nonuniform sample choice, handling and processing, blood cell contamination during sample preparation and the lack of consensus regarding data normalization. In this review, we discuss the value of circulating lncRNAs in the clinical setting, particularly with respect to their possible implementation as diagnostic and prognostic markers in cancer. Although the great potential of circulating lncRNAs as cancer biomarkers would be an important development in disease management, both intrinsic and extrinsic factors that may affect their measurement have not been fully characterized. Moreover, the clinical significance of circulating lncRNA may not be proven without a global consensus regarding procedures and standardized protocols for their detection. |
format | Online Article Text |
id | pubmed-4869386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48693862016-05-18 Circulating long non-coding RNAs in cancer: current status and future perspectives Qi, Peng Zhou, Xiao-yan Du, Xiang Mol Cancer Review Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studies demonstrating the feasibility of their use as tools in the diagnosis and prognosis of different types of malignancies and for predicting and possibly monitoring treatment response. However, critical issues are represented by nonuniform sample choice, handling and processing, blood cell contamination during sample preparation and the lack of consensus regarding data normalization. In this review, we discuss the value of circulating lncRNAs in the clinical setting, particularly with respect to their possible implementation as diagnostic and prognostic markers in cancer. Although the great potential of circulating lncRNAs as cancer biomarkers would be an important development in disease management, both intrinsic and extrinsic factors that may affect their measurement have not been fully characterized. Moreover, the clinical significance of circulating lncRNA may not be proven without a global consensus regarding procedures and standardized protocols for their detection. BioMed Central 2016-05-17 /pmc/articles/PMC4869386/ /pubmed/27189224 http://dx.doi.org/10.1186/s12943-016-0524-4 Text en © Qi et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Qi, Peng Zhou, Xiao-yan Du, Xiang Circulating long non-coding RNAs in cancer: current status and future perspectives |
title | Circulating long non-coding RNAs in cancer: current status and future perspectives |
title_full | Circulating long non-coding RNAs in cancer: current status and future perspectives |
title_fullStr | Circulating long non-coding RNAs in cancer: current status and future perspectives |
title_full_unstemmed | Circulating long non-coding RNAs in cancer: current status and future perspectives |
title_short | Circulating long non-coding RNAs in cancer: current status and future perspectives |
title_sort | circulating long non-coding rnas in cancer: current status and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869386/ https://www.ncbi.nlm.nih.gov/pubmed/27189224 http://dx.doi.org/10.1186/s12943-016-0524-4 |
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