Cargando…

Circulating long non-coding RNAs in cancer: current status and future perspectives

Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studi...

Descripción completa

Detalles Bibliográficos
Autores principales: Qi, Peng, Zhou, Xiao-yan, Du, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869386/
https://www.ncbi.nlm.nih.gov/pubmed/27189224
http://dx.doi.org/10.1186/s12943-016-0524-4
_version_ 1782432311748329472
author Qi, Peng
Zhou, Xiao-yan
Du, Xiang
author_facet Qi, Peng
Zhou, Xiao-yan
Du, Xiang
author_sort Qi, Peng
collection PubMed
description Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studies demonstrating the feasibility of their use as tools in the diagnosis and prognosis of different types of malignancies and for predicting and possibly monitoring treatment response. However, critical issues are represented by nonuniform sample choice, handling and processing, blood cell contamination during sample preparation and the lack of consensus regarding data normalization. In this review, we discuss the value of circulating lncRNAs in the clinical setting, particularly with respect to their possible implementation as diagnostic and prognostic markers in cancer. Although the great potential of circulating lncRNAs as cancer biomarkers would be an important development in disease management, both intrinsic and extrinsic factors that may affect their measurement have not been fully characterized. Moreover, the clinical significance of circulating lncRNA may not be proven without a global consensus regarding procedures and standardized protocols for their detection.
format Online
Article
Text
id pubmed-4869386
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-48693862016-05-18 Circulating long non-coding RNAs in cancer: current status and future perspectives Qi, Peng Zhou, Xiao-yan Du, Xiang Mol Cancer Review Long non-coding RNAs (lncRNAs) comprise a diverse class of RNA transcripts >200 nucleotides in length with limited protein-coding potential. In addition to their possible role in cancer biology, circulating lncRNAs have emerged as a new class of promising cancer biomarkers, with independent studies demonstrating the feasibility of their use as tools in the diagnosis and prognosis of different types of malignancies and for predicting and possibly monitoring treatment response. However, critical issues are represented by nonuniform sample choice, handling and processing, blood cell contamination during sample preparation and the lack of consensus regarding data normalization. In this review, we discuss the value of circulating lncRNAs in the clinical setting, particularly with respect to their possible implementation as diagnostic and prognostic markers in cancer. Although the great potential of circulating lncRNAs as cancer biomarkers would be an important development in disease management, both intrinsic and extrinsic factors that may affect their measurement have not been fully characterized. Moreover, the clinical significance of circulating lncRNA may not be proven without a global consensus regarding procedures and standardized protocols for their detection. BioMed Central 2016-05-17 /pmc/articles/PMC4869386/ /pubmed/27189224 http://dx.doi.org/10.1186/s12943-016-0524-4 Text en © Qi et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Qi, Peng
Zhou, Xiao-yan
Du, Xiang
Circulating long non-coding RNAs in cancer: current status and future perspectives
title Circulating long non-coding RNAs in cancer: current status and future perspectives
title_full Circulating long non-coding RNAs in cancer: current status and future perspectives
title_fullStr Circulating long non-coding RNAs in cancer: current status and future perspectives
title_full_unstemmed Circulating long non-coding RNAs in cancer: current status and future perspectives
title_short Circulating long non-coding RNAs in cancer: current status and future perspectives
title_sort circulating long non-coding rnas in cancer: current status and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869386/
https://www.ncbi.nlm.nih.gov/pubmed/27189224
http://dx.doi.org/10.1186/s12943-016-0524-4
work_keys_str_mv AT qipeng circulatinglongnoncodingrnasincancercurrentstatusandfutureperspectives
AT zhouxiaoyan circulatinglongnoncodingrnasincancercurrentstatusandfutureperspectives
AT duxiang circulatinglongnoncodingrnasincancercurrentstatusandfutureperspectives