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Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity

Amyloid beta (Aβ) peptide aggregation is linked to the initiation of Alzheimer's disease; accordingly, aggregation-prone isoforms of Aβ, expressed in the brain, shorten the lifespan of Drosophila melanogaster. However, the lethal effects of Aβ are not apparent until after day 15. We used shibir...

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Detalles Bibliográficos
Autores principales:	Ott, Stanislav, Vishnivetskaya, Anastasia, Malmendal, Anders, Crowther, Damian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869574/ https://www.ncbi.nlm.nih.gov/pubmed/27103517 http://dx.doi.org/10.1016/j.neurobiolaging.2016.01.009

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