Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst

Nickel(0)-catalyzed cross-coupling of heteroaryl-containing diarylmethanes with both aryl bromides and chlorides has been achieved. The success of this reaction relies on the introduction of a unique nickel/NIXANTPHOS-based catalyst system, which provides a direct route to triarylmethanes from heter...

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Autores principales: Cao, Xinyu, Sha, Sheng-Chun, Li, Minyan, Kim, Byeong-Seon, Morgan, Catherine, Huang, Rudan, Yang, Xiaodong, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869726/
https://www.ncbi.nlm.nih.gov/pubmed/27213035
http://dx.doi.org/10.1039/c5sc03704b
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author Cao, Xinyu
Sha, Sheng-Chun
Li, Minyan
Kim, Byeong-Seon
Morgan, Catherine
Huang, Rudan
Yang, Xiaodong
Walsh, Patrick J.
author_facet Cao, Xinyu
Sha, Sheng-Chun
Li, Minyan
Kim, Byeong-Seon
Morgan, Catherine
Huang, Rudan
Yang, Xiaodong
Walsh, Patrick J.
author_sort Cao, Xinyu
collection PubMed
description Nickel(0)-catalyzed cross-coupling of heteroaryl-containing diarylmethanes with both aryl bromides and chlorides has been achieved. The success of this reaction relies on the introduction of a unique nickel/NIXANTPHOS-based catalyst system, which provides a direct route to triarylmethanes from heteroaryl-containing diarylmethanes. Reactivity studies indicate the Ni(NIXANTPHOS)-based catalyst exhibits enhanced reactivity over XANTPHOS derivatives and other Ni(phosphine)-based catalysts in the reactions examined.
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spelling pubmed-48697262017-01-01 Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst Cao, Xinyu Sha, Sheng-Chun Li, Minyan Kim, Byeong-Seon Morgan, Catherine Huang, Rudan Yang, Xiaodong Walsh, Patrick J. Chem Sci Chemistry Nickel(0)-catalyzed cross-coupling of heteroaryl-containing diarylmethanes with both aryl bromides and chlorides has been achieved. The success of this reaction relies on the introduction of a unique nickel/NIXANTPHOS-based catalyst system, which provides a direct route to triarylmethanes from heteroaryl-containing diarylmethanes. Reactivity studies indicate the Ni(NIXANTPHOS)-based catalyst exhibits enhanced reactivity over XANTPHOS derivatives and other Ni(phosphine)-based catalysts in the reactions examined. Royal Society of Chemistry 2016-01-01 2015-10-26 /pmc/articles/PMC4869726/ /pubmed/27213035 http://dx.doi.org/10.1039/c5sc03704b Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Cao, Xinyu
Sha, Sheng-Chun
Li, Minyan
Kim, Byeong-Seon
Morgan, Catherine
Huang, Rudan
Yang, Xiaodong
Walsh, Patrick J.
Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
title Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
title_full Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
title_fullStr Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
title_full_unstemmed Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
title_short Nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the Ni(NIXANTPHOS)-based catalyst
title_sort nickel-catalyzed arylation of heteroaryl-containing diarylmethanes: exceptional reactivity of the ni(nixantphos)-based catalyst
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869726/
https://www.ncbi.nlm.nih.gov/pubmed/27213035
http://dx.doi.org/10.1039/c5sc03704b
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