Negative Ions Enhance Survival of Membrane Protein Complexes

Membrane protein complexes are commonly introduced to the mass spectrometer solubilized in detergent micelles. The collisional activation used to remove the detergent, however, often causes protein unfolding and dissociation. As in the case for soluble proteins, electrospray in the positive ion mode...

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Detalles Bibliográficos
Autores principales: Liko, Idlir, Hopper, Jonathan T. S., Allison, Timothy M., Benesch, Justin L. P., Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Focus: Mass Spectrometry as a Probe of Higher Order Protein Structure: Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869745/
https://www.ncbi.nlm.nih.gov/pubmed/27106602
http://dx.doi.org/10.1007/s13361-016-1381-5

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