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Altered mean platelet volume in patients with polymyositis and its association with disease severity

Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature...

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Autores principales: Peng, Y.-F., Huang, Y.-X., Wei, Y.-S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869824/
https://www.ncbi.nlm.nih.gov/pubmed/27191605
http://dx.doi.org/10.1590/1414-431X20165168
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author Peng, Y.-F.
Huang, Y.-X.
Wei, Y.-S.
author_facet Peng, Y.-F.
Huang, Y.-X.
Wei, Y.-S.
author_sort Peng, Y.-F.
collection PubMed
description Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature with respect to MPV levels in PM patients. Therefore, in this study we aimed to investigate MPV levels in patients with PM. This study included 92 newly diagnosed PM patients and 100 healthy individuals. MPV levels were found to be significantly lower compared with healthy controls (10.3±1.23 vs 11.5±0.74 fL, P<0.001). Interestingly, MPV was found to be positively correlated with manual muscle test (MMT) score and negatively correlated with erythrocyte sedimentation rate (ESR) in patients with PM (r=0.239, P=0.022; r=−0.268, P=0.010, respectively). In addition, MPV was significantly lower in active PM patients compared with inactive PM patients (9.9±1.39 vs 10.6±0.92 fL, P=0.010). MPV was independently associated with PM in multivariate regression analyses, when controlling for hemoglobin and ESR (OR=0.312, P=0.031, 95%CI=0.108 to 0.899). The ROC curve analysis for MPV in estimating PM patients resulted in an area under the curve of 0.800, with sensitivity of 75.0% and specificity of 67.4%. Our results suggest that MPV is inversely correlated with disease activity in patients with PM. MPV might be a useful tool for rapid assessment of disease severity in PM patients.
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spelling pubmed-48698242016-06-01 Altered mean platelet volume in patients with polymyositis and its association with disease severity Peng, Y.-F. Huang, Y.-X. Wei, Y.-S. Braz J Med Biol Res Clinical Investigation Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature with respect to MPV levels in PM patients. Therefore, in this study we aimed to investigate MPV levels in patients with PM. This study included 92 newly diagnosed PM patients and 100 healthy individuals. MPV levels were found to be significantly lower compared with healthy controls (10.3±1.23 vs 11.5±0.74 fL, P<0.001). Interestingly, MPV was found to be positively correlated with manual muscle test (MMT) score and negatively correlated with erythrocyte sedimentation rate (ESR) in patients with PM (r=0.239, P=0.022; r=−0.268, P=0.010, respectively). In addition, MPV was significantly lower in active PM patients compared with inactive PM patients (9.9±1.39 vs 10.6±0.92 fL, P=0.010). MPV was independently associated with PM in multivariate regression analyses, when controlling for hemoglobin and ESR (OR=0.312, P=0.031, 95%CI=0.108 to 0.899). The ROC curve analysis for MPV in estimating PM patients resulted in an area under the curve of 0.800, with sensitivity of 75.0% and specificity of 67.4%. Our results suggest that MPV is inversely correlated with disease activity in patients with PM. MPV might be a useful tool for rapid assessment of disease severity in PM patients. Associação Brasileira de Divulgação Científica 2016-05-13 /pmc/articles/PMC4869824/ /pubmed/27191605 http://dx.doi.org/10.1590/1414-431X20165168 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Peng, Y.-F.
Huang, Y.-X.
Wei, Y.-S.
Altered mean platelet volume in patients with polymyositis and its association with disease severity
title Altered mean platelet volume in patients with polymyositis and its association with disease severity
title_full Altered mean platelet volume in patients with polymyositis and its association with disease severity
title_fullStr Altered mean platelet volume in patients with polymyositis and its association with disease severity
title_full_unstemmed Altered mean platelet volume in patients with polymyositis and its association with disease severity
title_short Altered mean platelet volume in patients with polymyositis and its association with disease severity
title_sort altered mean platelet volume in patients with polymyositis and its association with disease severity
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869824/
https://www.ncbi.nlm.nih.gov/pubmed/27191605
http://dx.doi.org/10.1590/1414-431X20165168
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