Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient ho...

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Detalles Bibliográficos
Autores principales: Strakova, Andrea, Ní Leathlobhair, Máire, Wang, Guo-Dong, Yin, Ting-Ting, Airikkala-Otter, Ilona, Allen, Janice L, Allum, Karen M, Bansse-Issa, Leontine, Bisson, Jocelyn L, Castillo Domracheva, Artemio, de Castro, Karina F, Corrigan, Anne M, Cran, Hugh R, Crawford, Jane T, Cutter, Stephen M, Delgadillo Keenan, Laura, Donelan, Edward M, Faramade, Ibikunle A, Flores Reynoso, Erika, Fotopoulou, Eleni, Fruean, Skye N, Gallardo-Arrieta, Fanny, Glebova, Olga, Häfelin Manrique, Rodrigo F, Henriques, Joaquim JGP, Ignatenko, Natalia, Koenig, Debbie, Lanza-Perea, Marta, Lobetti, Remo, Lopez Quintana, Adriana M, Losfelt, Thibault, Marino, Gabriele, Martincorena, Inigo, Martínez Castañeda, Simón, Martínez-López, Mayra F, Meyer, Michael, Nakanwagi, Berna, De Nardi, Andrigo B, Neunzig, Winifred, Nixon, Sally J, Onsare, Marsden M, Ortega-Pacheco, Antonio, Peleteiro, Maria C, Pye, Ruth J, Reece, John F, Rojas Gutierrez, Jose, Sadia, Haleema, Schmeling, Sheila K, Shamanova, Olga, Ssuna, Richard K, Steenland-Smit, Audrey E, Svitich, Alla, Thoya Ngoka, Ismail, Vițălaru, Bogdan A, de Vos, Anna P, de Vos, Johan P, Walkinton, Oliver, Wedge, David C, Wehrle-Martinez, Alvaro S, van der Wel, Mirjam G, Widdowson, Sophie AE, Murchison, Elizabeth P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869914/
https://www.ncbi.nlm.nih.gov/pubmed/27185408
http://dx.doi.org/10.7554/eLife.14552
Descripción
Sumario:Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution. DOI: http://dx.doi.org/10.7554/eLife.14552.001

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