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Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient ho...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869914/ https://www.ncbi.nlm.nih.gov/pubmed/27185408 http://dx.doi.org/10.7554/eLife.14552 |
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| author | Strakova, Andrea Ní Leathlobhair, Máire Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L Allum, Karen M Bansse-Issa, Leontine Bisson, Jocelyn L Castillo Domracheva, Artemio de Castro, Karina F Corrigan, Anne M Cran, Hugh R Crawford, Jane T Cutter, Stephen M Delgadillo Keenan, Laura Donelan, Edward M Faramade, Ibikunle A Flores Reynoso, Erika Fotopoulou, Eleni Fruean, Skye N Gallardo-Arrieta, Fanny Glebova, Olga Häfelin Manrique, Rodrigo F Henriques, Joaquim JGP Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Martínez Castañeda, Simón Martínez-López, Mayra F Meyer, Michael Nakanwagi, Berna De Nardi, Andrigo B Neunzig, Winifred Nixon, Sally J Onsare, Marsden M Ortega-Pacheco, Antonio Peleteiro, Maria C Pye, Ruth J Reece, John F Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K Shamanova, Olga Ssuna, Richard K Steenland-Smit, Audrey E Svitich, Alla Thoya Ngoka, Ismail Vițălaru, Bogdan A de Vos, Anna P de Vos, Johan P Walkinton, Oliver Wedge, David C Wehrle-Martinez, Alvaro S van der Wel, Mirjam G Widdowson, Sophie AE Murchison, Elizabeth P |
| author_facet | Strakova, Andrea Ní Leathlobhair, Máire Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L Allum, Karen M Bansse-Issa, Leontine Bisson, Jocelyn L Castillo Domracheva, Artemio de Castro, Karina F Corrigan, Anne M Cran, Hugh R Crawford, Jane T Cutter, Stephen M Delgadillo Keenan, Laura Donelan, Edward M Faramade, Ibikunle A Flores Reynoso, Erika Fotopoulou, Eleni Fruean, Skye N Gallardo-Arrieta, Fanny Glebova, Olga Häfelin Manrique, Rodrigo F Henriques, Joaquim JGP Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Martínez Castañeda, Simón Martínez-López, Mayra F Meyer, Michael Nakanwagi, Berna De Nardi, Andrigo B Neunzig, Winifred Nixon, Sally J Onsare, Marsden M Ortega-Pacheco, Antonio Peleteiro, Maria C Pye, Ruth J Reece, John F Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K Shamanova, Olga Ssuna, Richard K Steenland-Smit, Audrey E Svitich, Alla Thoya Ngoka, Ismail Vițălaru, Bogdan A de Vos, Anna P de Vos, Johan P Walkinton, Oliver Wedge, David C Wehrle-Martinez, Alvaro S van der Wel, Mirjam G Widdowson, Sophie AE Murchison, Elizabeth P |
| author_sort | Strakova, Andrea |
| collection | PubMed |
| description | Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution. DOI: http://dx.doi.org/10.7554/eLife.14552.001 |
| format | Online Article Text |
| id | pubmed-4869914 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48699142016-05-18 Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer Strakova, Andrea Ní Leathlobhair, Máire Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L Allum, Karen M Bansse-Issa, Leontine Bisson, Jocelyn L Castillo Domracheva, Artemio de Castro, Karina F Corrigan, Anne M Cran, Hugh R Crawford, Jane T Cutter, Stephen M Delgadillo Keenan, Laura Donelan, Edward M Faramade, Ibikunle A Flores Reynoso, Erika Fotopoulou, Eleni Fruean, Skye N Gallardo-Arrieta, Fanny Glebova, Olga Häfelin Manrique, Rodrigo F Henriques, Joaquim JGP Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Martínez Castañeda, Simón Martínez-López, Mayra F Meyer, Michael Nakanwagi, Berna De Nardi, Andrigo B Neunzig, Winifred Nixon, Sally J Onsare, Marsden M Ortega-Pacheco, Antonio Peleteiro, Maria C Pye, Ruth J Reece, John F Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K Shamanova, Olga Ssuna, Richard K Steenland-Smit, Audrey E Svitich, Alla Thoya Ngoka, Ismail Vițălaru, Bogdan A de Vos, Anna P de Vos, Johan P Walkinton, Oliver Wedge, David C Wehrle-Martinez, Alvaro S van der Wel, Mirjam G Widdowson, Sophie AE Murchison, Elizabeth P eLife Cancer Biology Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution. DOI: http://dx.doi.org/10.7554/eLife.14552.001 eLife Sciences Publications, Ltd 2016-05-17 /pmc/articles/PMC4869914/ /pubmed/27185408 http://dx.doi.org/10.7554/eLife.14552 Text en © 2016, Strakova et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| spellingShingle | Cancer Biology Strakova, Andrea Ní Leathlobhair, Máire Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L Allum, Karen M Bansse-Issa, Leontine Bisson, Jocelyn L Castillo Domracheva, Artemio de Castro, Karina F Corrigan, Anne M Cran, Hugh R Crawford, Jane T Cutter, Stephen M Delgadillo Keenan, Laura Donelan, Edward M Faramade, Ibikunle A Flores Reynoso, Erika Fotopoulou, Eleni Fruean, Skye N Gallardo-Arrieta, Fanny Glebova, Olga Häfelin Manrique, Rodrigo F Henriques, Joaquim JGP Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Martínez Castañeda, Simón Martínez-López, Mayra F Meyer, Michael Nakanwagi, Berna De Nardi, Andrigo B Neunzig, Winifred Nixon, Sally J Onsare, Marsden M Ortega-Pacheco, Antonio Peleteiro, Maria C Pye, Ruth J Reece, John F Rojas Gutierrez, Jose Sadia, Haleema Schmeling, Sheila K Shamanova, Olga Ssuna, Richard K Steenland-Smit, Audrey E Svitich, Alla Thoya Ngoka, Ismail Vițălaru, Bogdan A de Vos, Anna P de Vos, Johan P Walkinton, Oliver Wedge, David C Wehrle-Martinez, Alvaro S van der Wel, Mirjam G Widdowson, Sophie AE Murchison, Elizabeth P Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_full | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_fullStr | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_full_unstemmed | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_short | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_sort | mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| topic | Cancer Biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869914/ https://www.ncbi.nlm.nih.gov/pubmed/27185408 http://dx.doi.org/10.7554/eLife.14552 |
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