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Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice
PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and...
Autores principales: | Tsokas, Panayiotis, Hsieh, Changchi, Yao, Yudong, Lesburguères, Edith, Wallace, Emma Jane Claire, Tcherepanov, Andrew, Jothianandan, Desingarao, Hartley, Benjamin Rush, Pan, Ling, Rivard, Bruno, Farese, Robert V, Sajan, Mini P, Bergold, Peter John, Hernández, Alejandro Iván, Cottrell, James E, Shouval, Harel Z, Fenton, André Antonio, Sacktor, Todd Charlton |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869915/ https://www.ncbi.nlm.nih.gov/pubmed/27187150 http://dx.doi.org/10.7554/eLife.14846 |
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