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Tumor-suppressing roles of miR-214 and miR-218 in breast cancer
MicroRNAs (miRNAs) are small non-coding RNAs that are key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function of tumor suppressors in various types of human cancers. However, the biological functions of miR-214 and miR-218 in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869936/ https://www.ncbi.nlm.nih.gov/pubmed/27109339 http://dx.doi.org/10.3892/or.2016.4749 |
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author | LIU, BO TIAN, YANFENG LI, FANG ZHAO, ZENGREN JIANG, XIA ZHAI, CONGJIE HAN, XIAODONG ZHANG, LIKE |
author_facet | LIU, BO TIAN, YANFENG LI, FANG ZHAO, ZENGREN JIANG, XIA ZHAI, CONGJIE HAN, XIAODONG ZHANG, LIKE |
author_sort | LIU, BO |
collection | PubMed |
description | MicroRNAs (miRNAs) are small non-coding RNAs that are key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function of tumor suppressors in various types of human cancers. However, the biological functions of miR-214 and miR-218 in breast cancer have not been elucidated completely. The present study evaluated the expression and biological function of miR-214 and miR-218 in human breast cancer. Our results revealed that the expression of miR-214 and miR-218 were significantly decreased in breast cancer tissues compared with adjacent tissues. The aberrant expression of miR-214 and miR-218 were negatively associated with Ki-67, and the miR-218 expression was positively associated with progesterone receptor (PR) in breast cancer tissues. In vitro, the cell proliferation and migration were decreased, cell apoptosis was induced, and cell cycle was also disturbed in miR-214 or miR-218 overexpressed breast cancer cells. Our results demonstrated that miR-214 and miR-218 function as tumor suppressors in breast cancer, and may become biomarkers and potential therapeutic targets in breast cancer. |
format | Online Article Text |
id | pubmed-4869936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-48699362016-05-20 Tumor-suppressing roles of miR-214 and miR-218 in breast cancer LIU, BO TIAN, YANFENG LI, FANG ZHAO, ZENGREN JIANG, XIA ZHAI, CONGJIE HAN, XIAODONG ZHANG, LIKE Oncol Rep Articles MicroRNAs (miRNAs) are small non-coding RNAs that are key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function of tumor suppressors in various types of human cancers. However, the biological functions of miR-214 and miR-218 in breast cancer have not been elucidated completely. The present study evaluated the expression and biological function of miR-214 and miR-218 in human breast cancer. Our results revealed that the expression of miR-214 and miR-218 were significantly decreased in breast cancer tissues compared with adjacent tissues. The aberrant expression of miR-214 and miR-218 were negatively associated with Ki-67, and the miR-218 expression was positively associated with progesterone receptor (PR) in breast cancer tissues. In vitro, the cell proliferation and migration were decreased, cell apoptosis was induced, and cell cycle was also disturbed in miR-214 or miR-218 overexpressed breast cancer cells. Our results demonstrated that miR-214 and miR-218 function as tumor suppressors in breast cancer, and may become biomarkers and potential therapeutic targets in breast cancer. D.A. Spandidos 2016-06 2016-04-15 /pmc/articles/PMC4869936/ /pubmed/27109339 http://dx.doi.org/10.3892/or.2016.4749 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles LIU, BO TIAN, YANFENG LI, FANG ZHAO, ZENGREN JIANG, XIA ZHAI, CONGJIE HAN, XIAODONG ZHANG, LIKE Tumor-suppressing roles of miR-214 and miR-218 in breast cancer |
title | Tumor-suppressing roles of miR-214 and miR-218 in breast cancer |
title_full | Tumor-suppressing roles of miR-214 and miR-218 in breast cancer |
title_fullStr | Tumor-suppressing roles of miR-214 and miR-218 in breast cancer |
title_full_unstemmed | Tumor-suppressing roles of miR-214 and miR-218 in breast cancer |
title_short | Tumor-suppressing roles of miR-214 and miR-218 in breast cancer |
title_sort | tumor-suppressing roles of mir-214 and mir-218 in breast cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869936/ https://www.ncbi.nlm.nih.gov/pubmed/27109339 http://dx.doi.org/10.3892/or.2016.4749 |
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