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Distinct Types of Feeding Related Neurons in Mouse Hypothalamus

The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons...

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Autores principales: Tang, Yan, Benusiglio, Diego, Grinevich, Valery, Lin, Longnian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870269/
https://www.ncbi.nlm.nih.gov/pubmed/27242460
http://dx.doi.org/10.3389/fnbeh.2016.00091
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author Tang, Yan
Benusiglio, Diego
Grinevich, Valery
Lin, Longnian
author_facet Tang, Yan
Benusiglio, Diego
Grinevich, Valery
Lin, Longnian
author_sort Tang, Yan
collection PubMed
description The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothalamus and their feeding behavior. Using tetrode-based in vivo recording technique, we identified various firing patterns of hypothalamic FRNs, which, after the initiation of food intake, can be sorted into four types: sharp increase (type I), slow increase (type II), sharp decrease (type III), and sustained decrease (type IV) of firing rates. The feeding-related firing response of FRNs was rigidly related to the duration of food intake and, to a less extent, associated with the type of food. The majority of these FRNs responded to glucose and leptin and exhibited electrophysiological characteristics of putative GABAergic neurons. In conclusion, our study demonstrated the diversity of neurons in the complex hypothalamic network coordinating food intake.
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spelling pubmed-48702692016-05-30 Distinct Types of Feeding Related Neurons in Mouse Hypothalamus Tang, Yan Benusiglio, Diego Grinevich, Valery Lin, Longnian Front Behav Neurosci Neuroscience The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothalamus and their feeding behavior. Using tetrode-based in vivo recording technique, we identified various firing patterns of hypothalamic FRNs, which, after the initiation of food intake, can be sorted into four types: sharp increase (type I), slow increase (type II), sharp decrease (type III), and sustained decrease (type IV) of firing rates. The feeding-related firing response of FRNs was rigidly related to the duration of food intake and, to a less extent, associated with the type of food. The majority of these FRNs responded to glucose and leptin and exhibited electrophysiological characteristics of putative GABAergic neurons. In conclusion, our study demonstrated the diversity of neurons in the complex hypothalamic network coordinating food intake. Frontiers Media S.A. 2016-05-18 /pmc/articles/PMC4870269/ /pubmed/27242460 http://dx.doi.org/10.3389/fnbeh.2016.00091 Text en Copyright © 2016 Tang, Benusiglio, Grinevich and Lin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tang, Yan
Benusiglio, Diego
Grinevich, Valery
Lin, Longnian
Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
title Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
title_full Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
title_fullStr Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
title_full_unstemmed Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
title_short Distinct Types of Feeding Related Neurons in Mouse Hypothalamus
title_sort distinct types of feeding related neurons in mouse hypothalamus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870269/
https://www.ncbi.nlm.nih.gov/pubmed/27242460
http://dx.doi.org/10.3389/fnbeh.2016.00091
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