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Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease

Introduction. Sickle cell disease (SCD) is characterized by hemoglobin S homozygosity, leading to hemolysis and vasoocclusion. The hemolysis releases arginase I, an enzyme that decreases the bioavailability of nitric oxide, worsening the symptoms. The different SCD haplotypes are related to clinical...

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Detalles Bibliográficos
Autores principales:	Moreira, J. A., Machado, R. P. G., Laurentino, M. R., Lemes, Romelia Pinheiro Gonçalves, Barbosa, M. C., Santos, T. E., Bandeira, I. C. J., Martins, A. M. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870341/ https://www.ncbi.nlm.nih.gov/pubmed/27274608 http://dx.doi.org/10.1155/2016/9172726

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