Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrh...

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Detalles Bibliográficos
Autores principales: Lu, Lunjie, Zhou, Jun, Zhang, Jingying, Che, Jun, Jiao, Yang, Zhang, Yusong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870345/
https://www.ncbi.nlm.nih.gov/pubmed/27274751
http://dx.doi.org/10.1155/2016/4097398
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author Lu, Lunjie
Zhou, Jun
Zhang, Jingying
Che, Jun
Jiao, Yang
Zhang, Yusong
author_facet Lu, Lunjie
Zhou, Jun
Zhang, Jingying
Che, Jun
Jiao, Yang
Zhang, Yusong
author_sort Lu, Lunjie
collection PubMed
description Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI.
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spelling pubmed-48703452016-06-05 Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model Lu, Lunjie Zhou, Jun Zhang, Jingying Che, Jun Jiao, Yang Zhang, Yusong Evid Based Complement Alternat Med Research Article Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI. Hindawi Publishing Corporation 2016 2016-05-04 /pmc/articles/PMC4870345/ /pubmed/27274751 http://dx.doi.org/10.1155/2016/4097398 Text en Copyright © 2016 Lunjie Lu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Lunjie
Zhou, Jun
Zhang, Jingying
Che, Jun
Jiao, Yang
Zhang, Yusong
Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
title Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
title_full Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
title_fullStr Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
title_full_unstemmed Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
title_short Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
title_sort prevention and therapeutic effects and mechanisms of tanshinone iia sodium sulfonate on acute liver injury mice model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870345/
https://www.ncbi.nlm.nih.gov/pubmed/27274751
http://dx.doi.org/10.1155/2016/4097398
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