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Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

Despite the approval of several anti-angiogenic therapies, clinical results remain unsatisfactory, and transient benefits are followed by rapid tumor recurrence. Here, we demonstrate potent anti-angiogenic efficacy of the multi-kinase inhibitors nintedanib and sunitinib in a mouse model of breast ca...

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Detalles Bibliográficos
Autores principales: Pisarsky, Laura, Bill, Ruben, Fagiani, Ernesta, Dimeloe, Sarah, Goosen, Ryan William, Hagmann, Jörg, Hess, Christoph, Christofori, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870473/
https://www.ncbi.nlm.nih.gov/pubmed/27134168
http://dx.doi.org/10.1016/j.celrep.2016.04.028