Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation

Physical and chemical insult-induced bone marrow (BM) damage often leads to lethality resulting from the depletion of hematopoietic stem and progenitor cells (HSPCs) and/or a deteriorated BM stroma. Notch signaling plays an important role in hematopoiesis, but whether it is involved in BM damage rem...

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Detalles Bibliográficos
Autores principales: Chen, Juan-Juan, Gao, Xiao-Tong, Yang, Lan, Fu, Wei, Liang, Liang, Li, Jun-Chang, Hu, Bin, Sun, Zhi-Jian, Huang, Si-Yong, Zhang, Yi-Zhe, Liang, Ying-Min, Qin, Hong-Yan, Han, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870557/
https://www.ncbi.nlm.nih.gov/pubmed/27188577
http://dx.doi.org/10.1038/srep26003

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