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SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer
SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870566/ https://www.ncbi.nlm.nih.gov/pubmed/27188720 http://dx.doi.org/10.1038/srep26136 |
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author | Liu, Huidi Mastriani, Emilio Yan, Zi-Qiao Yin, Si-Yuan Zeng, Zheng Wang, Hong Li, Qing-Hai Liu, Hong-Yu Wang, Xiaoyu Bao, Hong-Xia Zhou, Yu-Jie Kou, Jun-Jie Li, Dongsheng Li, Ting Liu, Jianrui Liu, Yongfang Yin, Lin Qiu, Li Gong, Liling Liu, Shu-Lin |
author_facet | Liu, Huidi Mastriani, Emilio Yan, Zi-Qiao Yin, Si-Yuan Zeng, Zheng Wang, Hong Li, Qing-Hai Liu, Hong-Yu Wang, Xiaoyu Bao, Hong-Xia Zhou, Yu-Jie Kou, Jun-Jie Li, Dongsheng Li, Ting Liu, Jianrui Liu, Yongfang Yin, Lin Qiu, Li Gong, Liling Liu, Shu-Lin |
author_sort | Liu, Huidi |
collection | PubMed |
description | SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pathway, using clinical specimens and microarray gene expression data from the GEO database, for their roles in breast cancer. We compared the expression levels of SOX7 and other co-expressed genes in the Wnt/β-catenin pathway and found that the expression of SOX7, SOX17 and SOX18 was all reduced significantly in the breast cancer tissues compared to normal controls. AXIN2 had the highest co-relativity with SOX7 in the Wnt/β-catenin signaling pathway. Clinicopathological analysis demonstrated that the down-regulated SOX7 was significantly correlated with advanced stages and poorly differentiated breast cancers. Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with β-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-β-catenin pathway in the breast tissue to affect the carcinogenesis process. Our results also showed Smad7 as the target of SOX7 and AXIN2 in controlling breast cancer progression through the Wnt/β-catenin signaling pathway. |
format | Online Article Text |
id | pubmed-4870566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48705662016-06-01 SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer Liu, Huidi Mastriani, Emilio Yan, Zi-Qiao Yin, Si-Yuan Zeng, Zheng Wang, Hong Li, Qing-Hai Liu, Hong-Yu Wang, Xiaoyu Bao, Hong-Xia Zhou, Yu-Jie Kou, Jun-Jie Li, Dongsheng Li, Ting Liu, Jianrui Liu, Yongfang Yin, Lin Qiu, Li Gong, Liling Liu, Shu-Lin Sci Rep Article SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pathway, using clinical specimens and microarray gene expression data from the GEO database, for their roles in breast cancer. We compared the expression levels of SOX7 and other co-expressed genes in the Wnt/β-catenin pathway and found that the expression of SOX7, SOX17 and SOX18 was all reduced significantly in the breast cancer tissues compared to normal controls. AXIN2 had the highest co-relativity with SOX7 in the Wnt/β-catenin signaling pathway. Clinicopathological analysis demonstrated that the down-regulated SOX7 was significantly correlated with advanced stages and poorly differentiated breast cancers. Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with β-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-β-catenin pathway in the breast tissue to affect the carcinogenesis process. Our results also showed Smad7 as the target of SOX7 and AXIN2 in controlling breast cancer progression through the Wnt/β-catenin signaling pathway. Nature Publishing Group 2016-05-18 /pmc/articles/PMC4870566/ /pubmed/27188720 http://dx.doi.org/10.1038/srep26136 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Huidi Mastriani, Emilio Yan, Zi-Qiao Yin, Si-Yuan Zeng, Zheng Wang, Hong Li, Qing-Hai Liu, Hong-Yu Wang, Xiaoyu Bao, Hong-Xia Zhou, Yu-Jie Kou, Jun-Jie Li, Dongsheng Li, Ting Liu, Jianrui Liu, Yongfang Yin, Lin Qiu, Li Gong, Liling Liu, Shu-Lin SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer |
title | SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer |
title_full | SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer |
title_fullStr | SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer |
title_full_unstemmed | SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer |
title_short | SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer |
title_sort | sox7 co-regulates wnt/β-catenin signaling with axin-2: both expressed at low levels in breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870566/ https://www.ncbi.nlm.nih.gov/pubmed/27188720 http://dx.doi.org/10.1038/srep26136 |
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