Interleukin-10 Family and Tuberculosis: An Old Story Renewed

The interleukin-10 (IL-10) family of cytokines consists of six immune mediators, namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. Specifically, IL-10 and IL-26 can suppress...

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Autores principales: Abdalla, Abualgasim Elgaili, Lambert, Nzungize, Duan, Xiangke, Xie, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870714/
https://www.ncbi.nlm.nih.gov/pubmed/27194948
http://dx.doi.org/10.7150/ijbs.13881
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author Abdalla, Abualgasim Elgaili
Lambert, Nzungize
Duan, Xiangke
Xie, Jianping
author_facet Abdalla, Abualgasim Elgaili
Lambert, Nzungize
Duan, Xiangke
Xie, Jianping
author_sort Abdalla, Abualgasim Elgaili
collection PubMed
description The interleukin-10 (IL-10) family of cytokines consists of six immune mediators, namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. Specifically, IL-10 and IL-26 can suppress the antimycobacterial immunity and promote the survival of pathogen, while IL-22 and IL-24 can generate protective responses and inhibit the intracellular growth of pathogen. Knowledge about the new players in tuberculosis immunology, namely IL-10 family, can inform novel immunity-based countermeasures and host directed therapies against tuberculosis.
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spelling pubmed-48707142016-05-18 Interleukin-10 Family and Tuberculosis: An Old Story Renewed Abdalla, Abualgasim Elgaili Lambert, Nzungize Duan, Xiangke Xie, Jianping Int J Biol Sci Review The interleukin-10 (IL-10) family of cytokines consists of six immune mediators, namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for the regulation of host defense against Mycobacterium tuberculosis infections. Specifically, IL-10 and IL-26 can suppress the antimycobacterial immunity and promote the survival of pathogen, while IL-22 and IL-24 can generate protective responses and inhibit the intracellular growth of pathogen. Knowledge about the new players in tuberculosis immunology, namely IL-10 family, can inform novel immunity-based countermeasures and host directed therapies against tuberculosis. Ivyspring International Publisher 2016-04-27 /pmc/articles/PMC4870714/ /pubmed/27194948 http://dx.doi.org/10.7150/ijbs.13881 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Review
Abdalla, Abualgasim Elgaili
Lambert, Nzungize
Duan, Xiangke
Xie, Jianping
Interleukin-10 Family and Tuberculosis: An Old Story Renewed
title Interleukin-10 Family and Tuberculosis: An Old Story Renewed
title_full Interleukin-10 Family and Tuberculosis: An Old Story Renewed
title_fullStr Interleukin-10 Family and Tuberculosis: An Old Story Renewed
title_full_unstemmed Interleukin-10 Family and Tuberculosis: An Old Story Renewed
title_short Interleukin-10 Family and Tuberculosis: An Old Story Renewed
title_sort interleukin-10 family and tuberculosis: an old story renewed
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870714/
https://www.ncbi.nlm.nih.gov/pubmed/27194948
http://dx.doi.org/10.7150/ijbs.13881
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