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The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematop...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870746/ https://www.ncbi.nlm.nih.gov/pubmed/27193054 http://dx.doi.org/10.1186/s13045-016-0276-z |
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author | Zhao, Ke Liu, Qifa |
author_facet | Zhao, Ke Liu, Qifa |
author_sort | Zhao, Ke |
collection | PubMed |
description | Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications. |
format | Online Article Text |
id | pubmed-4870746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48707462016-05-19 The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation Zhao, Ke Liu, Qifa J Hematol Oncol Review Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications. BioMed Central 2016-05-18 /pmc/articles/PMC4870746/ /pubmed/27193054 http://dx.doi.org/10.1186/s13045-016-0276-z Text en © Zhao and Liu. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Zhao, Ke Liu, Qifa The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
title | The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
title_full | The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
title_fullStr | The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
title_full_unstemmed | The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
title_short | The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
title_sort | clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870746/ https://www.ncbi.nlm.nih.gov/pubmed/27193054 http://dx.doi.org/10.1186/s13045-016-0276-z |
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