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The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematop...

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Detalles Bibliográficos
Autores principales: Zhao, Ke, Liu, Qifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870746/
https://www.ncbi.nlm.nih.gov/pubmed/27193054
http://dx.doi.org/10.1186/s13045-016-0276-z
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author Zhao, Ke
Liu, Qifa
author_facet Zhao, Ke
Liu, Qifa
author_sort Zhao, Ke
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description Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications.
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spelling pubmed-48707462016-05-19 The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation Zhao, Ke Liu, Qifa J Hematol Oncol Review Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications. BioMed Central 2016-05-18 /pmc/articles/PMC4870746/ /pubmed/27193054 http://dx.doi.org/10.1186/s13045-016-0276-z Text en © Zhao and Liu. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhao, Ke
Liu, Qifa
The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
title The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
title_full The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
title_fullStr The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
title_full_unstemmed The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
title_short The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
title_sort clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870746/
https://www.ncbi.nlm.nih.gov/pubmed/27193054
http://dx.doi.org/10.1186/s13045-016-0276-z
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