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CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
BACKGROUND: Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870763/ https://www.ncbi.nlm.nih.gov/pubmed/27193312 http://dx.doi.org/10.1186/s12890-016-0239-8 |
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author | Usemann, Jakob Frey, Urs Mack, Ines Schmidt, Anne Gorlanova, Olga Röösli, Martin Hartl, Dominik Latzin, Philipp |
author_facet | Usemann, Jakob Frey, Urs Mack, Ines Schmidt, Anne Gorlanova, Olga Röösli, Martin Hartl, Dominik Latzin, Philipp |
author_sort | Usemann, Jakob |
collection | PubMed |
description | BACKGROUND: Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential biomarkers for milder forms of asthma. We assessed in an unselected population whether SNPs in CHI3L1 and cord blood YKL-40 levels at birth are associated with respiratory symptoms, lung function changes, asthma, and atopy. METHODS: In a prospective birth cohort of healthy term-born neonates (n = 260), we studied CHI3L1 polymorphisms, and measured cord blood YKL-40 levels by ELISA in (n = 170) infants. Lung function was performed at 5 weeks and 6 years. Respiratory health during the first year of life was assessed weekly by telephone interviews. Diagnosis of asthma and allergic sensitisation was assessed at 6 years (n = 142). RESULTS: The SNP rs10399805 was significantly associated with asthma at 6 years. The odds ratio for asthma was 4.5 (95 % CI 1.59–12.94) per T-allele. This finding was unchanged when adjusting for cord blood YKL-40 levels. There was no significant association for cord blood YKL-40 levels and asthma. SNPs in CHI3L1 and cord blood YKL-40 were not associated with lung function measurements at 5 weeks and 6 years, respiratory symptoms in the first year, and allergic sensitisation at 6 years. CONCLUSION: Genetic variation in CHI3L1 might be related to the development of milder forms of asthma. Larger studies are warranted to establish the role of YKL-40 in that pathway. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-016-0239-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4870763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48707632016-05-19 CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development Usemann, Jakob Frey, Urs Mack, Ines Schmidt, Anne Gorlanova, Olga Röösli, Martin Hartl, Dominik Latzin, Philipp BMC Pulm Med Research Article BACKGROUND: Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential biomarkers for milder forms of asthma. We assessed in an unselected population whether SNPs in CHI3L1 and cord blood YKL-40 levels at birth are associated with respiratory symptoms, lung function changes, asthma, and atopy. METHODS: In a prospective birth cohort of healthy term-born neonates (n = 260), we studied CHI3L1 polymorphisms, and measured cord blood YKL-40 levels by ELISA in (n = 170) infants. Lung function was performed at 5 weeks and 6 years. Respiratory health during the first year of life was assessed weekly by telephone interviews. Diagnosis of asthma and allergic sensitisation was assessed at 6 years (n = 142). RESULTS: The SNP rs10399805 was significantly associated with asthma at 6 years. The odds ratio for asthma was 4.5 (95 % CI 1.59–12.94) per T-allele. This finding was unchanged when adjusting for cord blood YKL-40 levels. There was no significant association for cord blood YKL-40 levels and asthma. SNPs in CHI3L1 and cord blood YKL-40 were not associated with lung function measurements at 5 weeks and 6 years, respiratory symptoms in the first year, and allergic sensitisation at 6 years. CONCLUSION: Genetic variation in CHI3L1 might be related to the development of milder forms of asthma. Larger studies are warranted to establish the role of YKL-40 in that pathway. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-016-0239-8) contains supplementary material, which is available to authorized users. BioMed Central 2016-05-18 /pmc/articles/PMC4870763/ /pubmed/27193312 http://dx.doi.org/10.1186/s12890-016-0239-8 Text en © Usemann et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Usemann, Jakob Frey, Urs Mack, Ines Schmidt, Anne Gorlanova, Olga Röösli, Martin Hartl, Dominik Latzin, Philipp CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development |
title | CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development |
title_full | CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development |
title_fullStr | CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development |
title_full_unstemmed | CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development |
title_short | CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development |
title_sort | chi3l1 polymorphisms, cord blood ykl-40 levels and later asthma development |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870763/ https://www.ncbi.nlm.nih.gov/pubmed/27193312 http://dx.doi.org/10.1186/s12890-016-0239-8 |
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