Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β-amyloid and tau protein, respectively. In AD, tau becomes abnormally phosphorylated and aggregates to form intracellular depo...

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Detalles Bibliográficos
Autores principales: Lau, Dawn H. W., Hogseth, Marte, Phillips, Emma C., O’Neill, Michael J., Pooler, Amy M., Noble, Wendy, Hanger, Diane P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870772/
https://www.ncbi.nlm.nih.gov/pubmed/27193083
http://dx.doi.org/10.1186/s40478-016-0317-4

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