The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities

Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of m...

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Autores principales: Bernt, Kathrin M., Hunger, Stephen P., Neff, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870860/
https://www.ncbi.nlm.nih.gov/pubmed/27242978
http://dx.doi.org/10.3389/fped.2016.00049
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author Bernt, Kathrin M.
Hunger, Stephen P.
Neff, Tobias
author_facet Bernt, Kathrin M.
Hunger, Stephen P.
Neff, Tobias
author_sort Bernt, Kathrin M.
collection PubMed
description Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.
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spelling pubmed-48708602016-05-30 The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities Bernt, Kathrin M. Hunger, Stephen P. Neff, Tobias Front Pediatr Pediatrics Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients. Frontiers Media S.A. 2016-05-18 /pmc/articles/PMC4870860/ /pubmed/27242978 http://dx.doi.org/10.3389/fped.2016.00049 Text en Copyright © 2016 Bernt, Hunger and Neff. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Bernt, Kathrin M.
Hunger, Stephen P.
Neff, Tobias
The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities
title The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities
title_full The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities
title_fullStr The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities
title_full_unstemmed The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities
title_short The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) – Mechanisms and Opportunities
title_sort functional role of prc2 in early t-cell precursor acute lymphoblastic leukemia (etp-all) – mechanisms and opportunities
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870860/
https://www.ncbi.nlm.nih.gov/pubmed/27242978
http://dx.doi.org/10.3389/fped.2016.00049
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