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The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier
The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but al...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870896/ https://www.ncbi.nlm.nih.gov/pubmed/27212900 http://dx.doi.org/10.4103/1673-5374.180372 |
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author | Balusu, Sriram Brkic, Marjana Libert, Claude Vandenbroucke, Roosmarijn E. |
author_facet | Balusu, Sriram Brkic, Marjana Libert, Claude Vandenbroucke, Roosmarijn E. |
author_sort | Balusu, Sriram |
collection | PubMed |
description | The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but also present an active interface between blood and cerebrospinal fluid (CSF). CPE cells perform indispensable functions for the development, maintenance and functioning of the brain. Indeed, the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules, such as nutrients, neurotrophins, and growth factors, as well as by clearing toxic and undesirable molecules from CSF. The choroid plexus also acts as a selective entry gate for leukocytes into the brain. Recent findings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer's disease. In this review, we review some recent findings that highlight the importance of the CPE-CSF system in Alzheimer's disease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy. |
format | Online Article Text |
id | pubmed-4870896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48708962016-05-20 The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier Balusu, Sriram Brkic, Marjana Libert, Claude Vandenbroucke, Roosmarijn E. Neural Regen Res Invited Review The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial (CPE) cells surrounding fenestrated capillaries. These CPE cells not only form an anatomical barrier, called the blood-cerebrospinal fluid barrier (BCSFB), but also present an active interface between blood and cerebrospinal fluid (CSF). CPE cells perform indispensable functions for the development, maintenance and functioning of the brain. Indeed, the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules, such as nutrients, neurotrophins, and growth factors, as well as by clearing toxic and undesirable molecules from CSF. The choroid plexus also acts as a selective entry gate for leukocytes into the brain. Recent findings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer's disease. In this review, we review some recent findings that highlight the importance of the CPE-CSF system in Alzheimer's disease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy. Medknow Publications & Media Pvt Ltd 2016-04 /pmc/articles/PMC4870896/ /pubmed/27212900 http://dx.doi.org/10.4103/1673-5374.180372 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Balusu, Sriram Brkic, Marjana Libert, Claude Vandenbroucke, Roosmarijn E. The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier |
title | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier |
title_full | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier |
title_fullStr | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier |
title_full_unstemmed | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier |
title_short | The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier |
title_sort | choroid plexus-cerebrospinal fluid interface in alzheimer's disease: more than just a barrier |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870896/ https://www.ncbi.nlm.nih.gov/pubmed/27212900 http://dx.doi.org/10.4103/1673-5374.180372 |
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