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Senegenin inhibits neuronal apoptosis after spinal cord contusion injury
Senegenin has been shown to inhibit neuronal apoptosis, thereby exerting a neuroprotective effect. In the present study, we established a rat model of spinal cord contusion injury using the modified Allen's method. Three hours after injury, senegenin (30 mg/g) was injected into the tail vein fo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870927/ https://www.ncbi.nlm.nih.gov/pubmed/27212931 http://dx.doi.org/10.4103/1673-5374.180754 |
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author | Zhang, Shu-quan Wu, Min-fei Gu, Rui Liu, Jia-bei Li, Ye Zhu, Qing-san Jiang, Jin-lan |
author_facet | Zhang, Shu-quan Wu, Min-fei Gu, Rui Liu, Jia-bei Li, Ye Zhu, Qing-san Jiang, Jin-lan |
author_sort | Zhang, Shu-quan |
collection | PubMed |
description | Senegenin has been shown to inhibit neuronal apoptosis, thereby exerting a neuroprotective effect. In the present study, we established a rat model of spinal cord contusion injury using the modified Allen's method. Three hours after injury, senegenin (30 mg/g) was injected into the tail vein for 3 consecutive days. Senegenin reduced the size of syringomyelic cavities, and it substantially reduced the number of apoptotic cells in the spinal cord. At the site of injury, Bax and Caspase-3 mRNA and protein levels were decreased by senegenin, while Bcl-2 mRNA and protein levels were increased. Nerve fiber density was increased in the spinal cord proximal to the brain, and hindlimb motor function and electrophysiological properties of rat hindlimb were improved. Taken together, our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury. |
format | Online Article Text |
id | pubmed-4870927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48709272016-05-20 Senegenin inhibits neuronal apoptosis after spinal cord contusion injury Zhang, Shu-quan Wu, Min-fei Gu, Rui Liu, Jia-bei Li, Ye Zhu, Qing-san Jiang, Jin-lan Neural Regen Res Research Article Senegenin has been shown to inhibit neuronal apoptosis, thereby exerting a neuroprotective effect. In the present study, we established a rat model of spinal cord contusion injury using the modified Allen's method. Three hours after injury, senegenin (30 mg/g) was injected into the tail vein for 3 consecutive days. Senegenin reduced the size of syringomyelic cavities, and it substantially reduced the number of apoptotic cells in the spinal cord. At the site of injury, Bax and Caspase-3 mRNA and protein levels were decreased by senegenin, while Bcl-2 mRNA and protein levels were increased. Nerve fiber density was increased in the spinal cord proximal to the brain, and hindlimb motor function and electrophysiological properties of rat hindlimb were improved. Taken together, our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury. Medknow Publications & Media Pvt Ltd 2016-04 /pmc/articles/PMC4870927/ /pubmed/27212931 http://dx.doi.org/10.4103/1673-5374.180754 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Zhang, Shu-quan Wu, Min-fei Gu, Rui Liu, Jia-bei Li, Ye Zhu, Qing-san Jiang, Jin-lan Senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
title | Senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
title_full | Senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
title_fullStr | Senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
title_full_unstemmed | Senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
title_short | Senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
title_sort | senegenin inhibits neuronal apoptosis after spinal cord contusion injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870927/ https://www.ncbi.nlm.nih.gov/pubmed/27212931 http://dx.doi.org/10.4103/1673-5374.180754 |
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