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Cell cycle regulated transcription: from yeast to cancer
Recent studies have revealed exciting new functions for forkhead transcription factors in cell proliferation and development. Cell proliferation is a fundamental process controlled by multiple overlapping mechanisms, and the control of gene expression plays a major role in the orderly and timely div...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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F1000Research
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870989/ https://www.ncbi.nlm.nih.gov/pubmed/27239285 http://dx.doi.org/10.12688/f1000research.8111.1 |
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author | McInerny, Christopher J. |
author_facet | McInerny, Christopher J. |
author_sort | McInerny, Christopher J. |
collection | PubMed |
description | Recent studies have revealed exciting new functions for forkhead transcription factors in cell proliferation and development. Cell proliferation is a fundamental process controlled by multiple overlapping mechanisms, and the control of gene expression plays a major role in the orderly and timely division of cells. This occurs through transcription factors regulating the expression of groups of genes at particular phases of the cell division cycle. In this way, the encoded gene products are present when they are required. This review outlines recent advances in our understanding of this process in yeast model systems and describes how this knowledge has informed analysis in more developmentally complex eukaryotes, particularly where it is relevant to human disease. |
format | Online Article Text |
id | pubmed-4870989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-48709892016-05-26 Cell cycle regulated transcription: from yeast to cancer McInerny, Christopher J. F1000Res Review Recent studies have revealed exciting new functions for forkhead transcription factors in cell proliferation and development. Cell proliferation is a fundamental process controlled by multiple overlapping mechanisms, and the control of gene expression plays a major role in the orderly and timely division of cells. This occurs through transcription factors regulating the expression of groups of genes at particular phases of the cell division cycle. In this way, the encoded gene products are present when they are required. This review outlines recent advances in our understanding of this process in yeast model systems and describes how this knowledge has informed analysis in more developmentally complex eukaryotes, particularly where it is relevant to human disease. F1000Research 2016-05-12 /pmc/articles/PMC4870989/ /pubmed/27239285 http://dx.doi.org/10.12688/f1000research.8111.1 Text en Copyright: © 2016 McInerny CJ http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review McInerny, Christopher J. Cell cycle regulated transcription: from yeast to cancer |
title | Cell cycle regulated transcription: from yeast to cancer |
title_full | Cell cycle regulated transcription: from yeast to cancer |
title_fullStr | Cell cycle regulated transcription: from yeast to cancer |
title_full_unstemmed | Cell cycle regulated transcription: from yeast to cancer |
title_short | Cell cycle regulated transcription: from yeast to cancer |
title_sort | cell cycle regulated transcription: from yeast to cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870989/ https://www.ncbi.nlm.nih.gov/pubmed/27239285 http://dx.doi.org/10.12688/f1000research.8111.1 |
work_keys_str_mv | AT mcinernychristopherj cellcycleregulatedtranscriptionfromyeasttocancer |