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Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au(core)-Ag(shell) nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871084/ https://www.ncbi.nlm.nih.gov/pubmed/27231624 http://dx.doi.org/10.1364/BOE.7.001830 |
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author | Shi, Yiwen Peng, Dong Wang, Kun Chai, Xinyu Ren, Qiushi Tian, Jie Zhou, Chuanqing |
author_facet | Shi, Yiwen Peng, Dong Wang, Kun Chai, Xinyu Ren, Qiushi Tian, Jie Zhou, Chuanqing |
author_sort | Shi, Yiwen |
collection | PubMed |
description | Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au(core)-Ag(shell) nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 °C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. |
format | Online Article Text |
id | pubmed-4871084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-48710842016-05-26 Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy Shi, Yiwen Peng, Dong Wang, Kun Chai, Xinyu Ren, Qiushi Tian, Jie Zhou, Chuanqing Biomed Opt Express Article Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au(core)-Ag(shell) nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 °C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. Optical Society of America 2016-04-12 /pmc/articles/PMC4871084/ /pubmed/27231624 http://dx.doi.org/10.1364/BOE.7.001830 Text en © 2016 Optical Society of America |
spellingShingle | Article Shi, Yiwen Peng, Dong Wang, Kun Chai, Xinyu Ren, Qiushi Tian, Jie Zhou, Chuanqing Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
title | Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
title_full | Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
title_fullStr | Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
title_full_unstemmed | Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
title_short | Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
title_sort | targeted aucore-agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871084/ https://www.ncbi.nlm.nih.gov/pubmed/27231624 http://dx.doi.org/10.1364/BOE.7.001830 |
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