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Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy

Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au(core)-Ag(shell) nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong...

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Autores principales: Shi, Yiwen, Peng, Dong, Wang, Kun, Chai, Xinyu, Ren, Qiushi, Tian, Jie, Zhou, Chuanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871084/
https://www.ncbi.nlm.nih.gov/pubmed/27231624
http://dx.doi.org/10.1364/BOE.7.001830
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author Shi, Yiwen
Peng, Dong
Wang, Kun
Chai, Xinyu
Ren, Qiushi
Tian, Jie
Zhou, Chuanqing
author_facet Shi, Yiwen
Peng, Dong
Wang, Kun
Chai, Xinyu
Ren, Qiushi
Tian, Jie
Zhou, Chuanqing
author_sort Shi, Yiwen
collection PubMed
description Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au(core)-Ag(shell) nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 °C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer.
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spelling pubmed-48710842016-05-26 Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy Shi, Yiwen Peng, Dong Wang, Kun Chai, Xinyu Ren, Qiushi Tian, Jie Zhou, Chuanqing Biomed Opt Express Article Optimizing contrast enhancement is essential for producing specific signals in biomedical imaging and therapy. The potential of using Au(core)-Ag(shell) nanorods (Au@Ag NRs) as a dual-functional theranostic contrast agent is demonstrated for effective cancer imaging and treatments. Due to its strong NIR absorption and high efficiency of photothermal conversion, effects of both photoacoustic tomography (PAT) and photothermal therapy (PTT) are enhanced significantly. The PAT signal grows by 45.3% and 82% in the phantom and in vivo experiments, respectively, when compared to those using Au NRs. In PTT, The maximum increase of tissue temperature treated with Au@Ag NRs is 22.8 °C, twice that with Au NRs. Results of the current study show the feasibility of using Au@Ag NRs for synergetic PAT with PTT. And it will enhance the potential application on real-time PAT guided PTT, which will greatly benefit the customized PTT treatment of cancer. Optical Society of America 2016-04-12 /pmc/articles/PMC4871084/ /pubmed/27231624 http://dx.doi.org/10.1364/BOE.7.001830 Text en © 2016 Optical Society of America
spellingShingle Article
Shi, Yiwen
Peng, Dong
Wang, Kun
Chai, Xinyu
Ren, Qiushi
Tian, Jie
Zhou, Chuanqing
Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
title Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
title_full Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
title_fullStr Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
title_full_unstemmed Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
title_short Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
title_sort targeted aucore-agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871084/
https://www.ncbi.nlm.nih.gov/pubmed/27231624
http://dx.doi.org/10.1364/BOE.7.001830
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