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Comparative Error-Free and Error-Prone Translesion Synthesis of N(2)-2′-Deoxyguanosine Adducts Formed by Mitomycin C and Its Metabolite, 2,7-Diaminomitosene, in Human Cells

[Image: see text] Mitomycin C (MC) is a cytotoxic and mutagenic antitumor agent that alkylates DNA upon reductive activation. 2,7-Diaminomitosene (2,7-DAM) is a major metabolite of MC in tumor cells, which also alkylates DNA. MC forms seven DNA adducts, including monoadducts and inter- and intrastra...

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Detalles Bibliográficos
Autores principales:	Bose, Arindam, Surugihalli, Chaitra, Pande, Paritosh, Champeil, Elise, Basu, Ashis K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871107/ https://www.ncbi.nlm.nih.gov/pubmed/27082015 http://dx.doi.org/10.1021/acs.chemrestox.6b00087

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