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Comparative Error-Free and Error-Prone Translesion Synthesis of N(2)-2′-Deoxyguanosine Adducts Formed by Mitomycin C and Its Metabolite, 2,7-Diaminomitosene, in Human Cells
[Image: see text] Mitomycin C (MC) is a cytotoxic and mutagenic antitumor agent that alkylates DNA upon reductive activation. 2,7-Diaminomitosene (2,7-DAM) is a major metabolite of MC in tumor cells, which also alkylates DNA. MC forms seven DNA adducts, including monoadducts and inter- and intrastra...
Autores principales: | Bose, Arindam, Surugihalli, Chaitra, Pande, Paritosh, Champeil, Elise, Basu, Ashis K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2016
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871107/ https://www.ncbi.nlm.nih.gov/pubmed/27082015 http://dx.doi.org/10.1021/acs.chemrestox.6b00087 |
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