Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones

A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a–c, 14–16a,b was synthesized in 78–87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a–c, 13a–e with...

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Autores principales: Demchenko, Anatoly, Bobkova, Ludmila, Yadlovskiy, Oleh, Buchtiarova, Tatiana, Demchenko, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871179/
https://www.ncbi.nlm.nih.gov/pubmed/27222602
http://dx.doi.org/10.3797/scipharm.1505-16
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author Demchenko, Anatoly
Bobkova, Ludmila
Yadlovskiy, Oleh
Buchtiarova, Tatiana
Demchenko, Sergey
author_facet Demchenko, Anatoly
Bobkova, Ludmila
Yadlovskiy, Oleh
Buchtiarova, Tatiana
Demchenko, Sergey
author_sort Demchenko, Anatoly
collection PubMed
description A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a–c, 14–16a,b was synthesized in 78–87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a–c, 13a–e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. All compounds have been characterized by (1)H-NMR, (13)C-NMR spectroscopy, and liquid chromatography–mass spectrometry.
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spelling pubmed-48711792016-05-24 Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones Demchenko, Anatoly Bobkova, Ludmila Yadlovskiy, Oleh Buchtiarova, Tatiana Demchenko, Sergey Sci Pharm Research Article A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a–c, 14–16a,b was synthesized in 78–87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a–c, 13a–e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. All compounds have been characterized by (1)H-NMR, (13)C-NMR spectroscopy, and liquid chromatography–mass spectrometry. The Austrian Journal of Pharmaceutical Sciences 2016 2015-08-27 /pmc/articles/PMC4871179/ /pubmed/27222602 http://dx.doi.org/10.3797/scipharm.1505-16 Text en Copyright: © Demchenko et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Demchenko, Anatoly
Bobkova, Ludmila
Yadlovskiy, Oleh
Buchtiarova, Tatiana
Demchenko, Sergey
Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones
title Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones
title_full Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones
title_fullStr Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones
title_full_unstemmed Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones
title_short Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones
title_sort synthesis and biological activity of new [1,3]thiazolo[4,5-d]pyridazin-4(5h)-ones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871179/
https://www.ncbi.nlm.nih.gov/pubmed/27222602
http://dx.doi.org/10.3797/scipharm.1505-16
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