Synthesis and Characterization of Compounds Related to Lisinopril

Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterizat...

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Detalles Bibliográficos
Autores principales: Raghava Reddy, Ambati V., Garaga, Srinivas, Takshinamoorthy, Chandiran, Naidu, Andra, Dandala, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871180/
https://www.ncbi.nlm.nih.gov/pubmed/27222603
http://dx.doi.org/10.3797/scipharm.1507-08
Descripción
Sumario:Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).

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