Synthesis and Characterization of Compounds Related to Lisinopril

Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterizat...

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Detalles Bibliográficos
Autores principales: Raghava Reddy, Ambati V., Garaga, Srinivas, Takshinamoorthy, Chandiran, Naidu, Andra, Dandala, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871180/
https://www.ncbi.nlm.nih.gov/pubmed/27222603
http://dx.doi.org/10.3797/scipharm.1507-08
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author Raghava Reddy, Ambati V.
Garaga, Srinivas
Takshinamoorthy, Chandiran
Naidu, Andra
Dandala, Ramesh
author_facet Raghava Reddy, Ambati V.
Garaga, Srinivas
Takshinamoorthy, Chandiran
Naidu, Andra
Dandala, Ramesh
author_sort Raghava Reddy, Ambati V.
collection PubMed
description Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
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spelling pubmed-48711802016-05-24 Synthesis and Characterization of Compounds Related to Lisinopril Raghava Reddy, Ambati V. Garaga, Srinivas Takshinamoorthy, Chandiran Naidu, Andra Dandala, Ramesh Sci Pharm Research Article Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F). The Austrian Journal of Pharmaceutical Sciences 2016 2015-10-18 /pmc/articles/PMC4871180/ /pubmed/27222603 http://dx.doi.org/10.3797/scipharm.1507-08 Text en Copyright: © Raghava Reddy et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Raghava Reddy, Ambati V.
Garaga, Srinivas
Takshinamoorthy, Chandiran
Naidu, Andra
Dandala, Ramesh
Synthesis and Characterization of Compounds Related to Lisinopril
title Synthesis and Characterization of Compounds Related to Lisinopril
title_full Synthesis and Characterization of Compounds Related to Lisinopril
title_fullStr Synthesis and Characterization of Compounds Related to Lisinopril
title_full_unstemmed Synthesis and Characterization of Compounds Related to Lisinopril
title_short Synthesis and Characterization of Compounds Related to Lisinopril
title_sort synthesis and characterization of compounds related to lisinopril
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871180/
https://www.ncbi.nlm.nih.gov/pubmed/27222603
http://dx.doi.org/10.3797/scipharm.1507-08
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