Cargando…

Nanoparticle biointerfacing via platelet membrane cloaking

Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can negatively impact nanoparticle effectiveness in complex, physiologically relevant systems(1–3). Despite the advances in bottom-up nanoengineering and surface chemistry, red...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Che-Ming J., Fang, Ronnie H., Wang, Kuei-Chun, Luk, Brian T., Thamphiwatana, Soracha, Dehaini, Diana, Nguyen, Phu, Angsantikul, Pavimol, Wen, Cindy H., Kroll, Ashley V., Carpenter, Cody, Ramesh, Manikantan, Qu, Vivian, Patel, Sherrina, Zhu, Jie, Shi, William, Hofman, Florence M., Chen, Thomas C., Gao, Weiwei, Zhang, Kang, Chien, Shu, Zhang, Liangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871317/
https://www.ncbi.nlm.nih.gov/pubmed/26374997
http://dx.doi.org/10.1038/nature15373
_version_ 1782432564303101952
author Hu, Che-Ming J.
Fang, Ronnie H.
Wang, Kuei-Chun
Luk, Brian T.
Thamphiwatana, Soracha
Dehaini, Diana
Nguyen, Phu
Angsantikul, Pavimol
Wen, Cindy H.
Kroll, Ashley V.
Carpenter, Cody
Ramesh, Manikantan
Qu, Vivian
Patel, Sherrina
Zhu, Jie
Shi, William
Hofman, Florence M.
Chen, Thomas C.
Gao, Weiwei
Zhang, Kang
Chien, Shu
Zhang, Liangfang
author_facet Hu, Che-Ming J.
Fang, Ronnie H.
Wang, Kuei-Chun
Luk, Brian T.
Thamphiwatana, Soracha
Dehaini, Diana
Nguyen, Phu
Angsantikul, Pavimol
Wen, Cindy H.
Kroll, Ashley V.
Carpenter, Cody
Ramesh, Manikantan
Qu, Vivian
Patel, Sherrina
Zhu, Jie
Shi, William
Hofman, Florence M.
Chen, Thomas C.
Gao, Weiwei
Zhang, Kang
Chien, Shu
Zhang, Liangfang
author_sort Hu, Che-Ming J.
collection PubMed
description Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can negatively impact nanoparticle effectiveness in complex, physiologically relevant systems(1–3). Despite the advances in bottom-up nanoengineering and surface chemistry, reductionist functionalization approaches remain inadequate in replicating the complex interfaces present in nature and cannot avoid exposure of foreign materials. Here we report on the preparation of polymeric nanoparticles enclosed in the plasma membrane of human platelets, which are a unique population of cellular fragments that adhere to a variety of disease-relevant substrates(4–7). The resulting nanoparticles possess a right-side-out unilamellar membrane coating functionalized with immunomodulatory and adhesion antigens associated with platelets. As compared to uncoated particles, the platelet membrane-cloaked nanoparticles have reduced cellular uptake by macrophage-like cells and are absent of particle-induced complement activation in autologous human plasma. The cloaked nanoparticles also display platelet-mimicking properties such as selective adhesion to damaged human and rodent vasculatures as well as enhanced binding to platelet-adhering pathogens. In an experimental rat model of coronary restenosis and a mouse model of systemic bacterial infection, docetaxel and vancomycin, respectively, show enhanced therapeutic efficacy when delivered by the platelet-mimetic nanoparticles. The multifaceted biointerfacing enabled by the platelet membrane cloaking method provides a new approach in developing functional nanoparticles for disease-targeted delivery.
format Online
Article
Text
id pubmed-4871317
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-48713172016-05-18 Nanoparticle biointerfacing via platelet membrane cloaking Hu, Che-Ming J. Fang, Ronnie H. Wang, Kuei-Chun Luk, Brian T. Thamphiwatana, Soracha Dehaini, Diana Nguyen, Phu Angsantikul, Pavimol Wen, Cindy H. Kroll, Ashley V. Carpenter, Cody Ramesh, Manikantan Qu, Vivian Patel, Sherrina Zhu, Jie Shi, William Hofman, Florence M. Chen, Thomas C. Gao, Weiwei Zhang, Kang Chien, Shu Zhang, Liangfang Nature Article Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can negatively impact nanoparticle effectiveness in complex, physiologically relevant systems(1–3). Despite the advances in bottom-up nanoengineering and surface chemistry, reductionist functionalization approaches remain inadequate in replicating the complex interfaces present in nature and cannot avoid exposure of foreign materials. Here we report on the preparation of polymeric nanoparticles enclosed in the plasma membrane of human platelets, which are a unique population of cellular fragments that adhere to a variety of disease-relevant substrates(4–7). The resulting nanoparticles possess a right-side-out unilamellar membrane coating functionalized with immunomodulatory and adhesion antigens associated with platelets. As compared to uncoated particles, the platelet membrane-cloaked nanoparticles have reduced cellular uptake by macrophage-like cells and are absent of particle-induced complement activation in autologous human plasma. The cloaked nanoparticles also display platelet-mimicking properties such as selective adhesion to damaged human and rodent vasculatures as well as enhanced binding to platelet-adhering pathogens. In an experimental rat model of coronary restenosis and a mouse model of systemic bacterial infection, docetaxel and vancomycin, respectively, show enhanced therapeutic efficacy when delivered by the platelet-mimetic nanoparticles. The multifaceted biointerfacing enabled by the platelet membrane cloaking method provides a new approach in developing functional nanoparticles for disease-targeted delivery. 2015-09-16 2015-10-01 /pmc/articles/PMC4871317/ /pubmed/26374997 http://dx.doi.org/10.1038/nature15373 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hu, Che-Ming J.
Fang, Ronnie H.
Wang, Kuei-Chun
Luk, Brian T.
Thamphiwatana, Soracha
Dehaini, Diana
Nguyen, Phu
Angsantikul, Pavimol
Wen, Cindy H.
Kroll, Ashley V.
Carpenter, Cody
Ramesh, Manikantan
Qu, Vivian
Patel, Sherrina
Zhu, Jie
Shi, William
Hofman, Florence M.
Chen, Thomas C.
Gao, Weiwei
Zhang, Kang
Chien, Shu
Zhang, Liangfang
Nanoparticle biointerfacing via platelet membrane cloaking
title Nanoparticle biointerfacing via platelet membrane cloaking
title_full Nanoparticle biointerfacing via platelet membrane cloaking
title_fullStr Nanoparticle biointerfacing via platelet membrane cloaking
title_full_unstemmed Nanoparticle biointerfacing via platelet membrane cloaking
title_short Nanoparticle biointerfacing via platelet membrane cloaking
title_sort nanoparticle biointerfacing via platelet membrane cloaking
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871317/
https://www.ncbi.nlm.nih.gov/pubmed/26374997
http://dx.doi.org/10.1038/nature15373
work_keys_str_mv AT huchemingj nanoparticlebiointerfacingviaplateletmembranecloaking
AT fangronnieh nanoparticlebiointerfacingviaplateletmembranecloaking
AT wangkueichun nanoparticlebiointerfacingviaplateletmembranecloaking
AT lukbriant nanoparticlebiointerfacingviaplateletmembranecloaking
AT thamphiwatanasoracha nanoparticlebiointerfacingviaplateletmembranecloaking
AT dehainidiana nanoparticlebiointerfacingviaplateletmembranecloaking
AT nguyenphu nanoparticlebiointerfacingviaplateletmembranecloaking
AT angsantikulpavimol nanoparticlebiointerfacingviaplateletmembranecloaking
AT wencindyh nanoparticlebiointerfacingviaplateletmembranecloaking
AT krollashleyv nanoparticlebiointerfacingviaplateletmembranecloaking
AT carpentercody nanoparticlebiointerfacingviaplateletmembranecloaking
AT rameshmanikantan nanoparticlebiointerfacingviaplateletmembranecloaking
AT quvivian nanoparticlebiointerfacingviaplateletmembranecloaking
AT patelsherrina nanoparticlebiointerfacingviaplateletmembranecloaking
AT zhujie nanoparticlebiointerfacingviaplateletmembranecloaking
AT shiwilliam nanoparticlebiointerfacingviaplateletmembranecloaking
AT hofmanflorencem nanoparticlebiointerfacingviaplateletmembranecloaking
AT chenthomasc nanoparticlebiointerfacingviaplateletmembranecloaking
AT gaoweiwei nanoparticlebiointerfacingviaplateletmembranecloaking
AT zhangkang nanoparticlebiointerfacingviaplateletmembranecloaking
AT chienshu nanoparticlebiointerfacingviaplateletmembranecloaking
AT zhangliangfang nanoparticlebiointerfacingviaplateletmembranecloaking