G-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics Simulation

The efficacy and bias of signal transduction induced by a drug at a target protein are closely associated with the benefits and side effects of the drug. In particular, partial agonist activity and G-protein/β-arrestin-biased agonist activity for the G-protein-coupled receptor (GPCR) family, the fam...

Descripción completa

Detalles Bibliográficos
Autores principales: Ichikawa, Osamu, Fujimoto, Kazushi, Yamada, Atsushi, Okazaki, Susumu, Yamazaki, Kazuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871340/
https://www.ncbi.nlm.nih.gov/pubmed/27187591
http://dx.doi.org/10.1371/journal.pone.0155816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871340/
https://www.ncbi.nlm.nih.gov/pubmed/27187591
http://dx.doi.org/10.1371/journal.pone.0155816

Ejemplares similares