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Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men

OBJECTIVES: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. MATERIALS AND METHODS: 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT),...

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Autores principales: Yamaçake, K. G. R., Cocuzza, M., Torricelli, F. C. M., Tiseo, B. C., Frati, R., Freire, G. C., Antunes, A. A., Srougi, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Urologia 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871400/
https://www.ncbi.nlm.nih.gov/pubmed/27256193
http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.0594
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author Yamaçake, K. G. R.
Cocuzza, M.
Torricelli, F. C. M.
Tiseo, B. C.
Frati, R.
Freire, G. C.
Antunes, A. A.
Srougi, M.
author_facet Yamaçake, K. G. R.
Cocuzza, M.
Torricelli, F. C. M.
Tiseo, B. C.
Frati, R.
Freire, G. C.
Antunes, A. A.
Srougi, M.
author_sort Yamaçake, K. G. R.
collection PubMed
description OBJECTIVES: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. MATERIALS AND METHODS: 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicular stimulating hormone (FSH). Patients were divided in groups according to their BMI in underweight, normal weight, overweight and obese grades 1, 2 or 3. First, it was studied the association between age, BMI, and hormone profile. Then, clinical varicocele was evaluated in 298 patients to assess its correlation to the others parameters. RESULTS: Obese patients had lower levels of TT, FT and SHBG (p<0.001) compared to underweight or normal weight patients. There were no differences in age (p=0.113), FSH serum levels (p=0.863) and LH serum levels (p=0.218) between obese and non-obese patients. Obese grade 3 had lower levels of TT and FT compared to obese grade 1 and 2 (p<0.05). There was no difference in the SHBG levels (p=0.120) among obese patients. There was no association between varicocele and BMI; and varicocele did not impact on testosterone or SHBG levels. CONCLUSIONS: Men with higher BMI have a lower serum level of TT, FT and SHBG. The presence of clinical varicocele as well as its grade has no impact on hormone profile in elderly men.
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spelling pubmed-48714002016-05-19 Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men Yamaçake, K. G. R. Cocuzza, M. Torricelli, F. C. M. Tiseo, B. C. Frati, R. Freire, G. C. Antunes, A. A. Srougi, M. Int Braz J Urol Original Article OBJECTIVES: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. MATERIALS AND METHODS: 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicular stimulating hormone (FSH). Patients were divided in groups according to their BMI in underweight, normal weight, overweight and obese grades 1, 2 or 3. First, it was studied the association between age, BMI, and hormone profile. Then, clinical varicocele was evaluated in 298 patients to assess its correlation to the others parameters. RESULTS: Obese patients had lower levels of TT, FT and SHBG (p<0.001) compared to underweight or normal weight patients. There were no differences in age (p=0.113), FSH serum levels (p=0.863) and LH serum levels (p=0.218) between obese and non-obese patients. Obese grade 3 had lower levels of TT and FT compared to obese grade 1 and 2 (p<0.05). There was no difference in the SHBG levels (p=0.120) among obese patients. There was no association between varicocele and BMI; and varicocele did not impact on testosterone or SHBG levels. CONCLUSIONS: Men with higher BMI have a lower serum level of TT, FT and SHBG. The presence of clinical varicocele as well as its grade has no impact on hormone profile in elderly men. Sociedade Brasileira de Urologia 2016 /pmc/articles/PMC4871400/ /pubmed/27256193 http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.0594 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yamaçake, K. G. R.
Cocuzza, M.
Torricelli, F. C. M.
Tiseo, B. C.
Frati, R.
Freire, G. C.
Antunes, A. A.
Srougi, M.
Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
title Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
title_full Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
title_fullStr Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
title_full_unstemmed Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
title_short Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
title_sort impact of body mass index, age and varicocele on reproductive hormone profile from elderly men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871400/
https://www.ncbi.nlm.nih.gov/pubmed/27256193
http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.0594
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