JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection

Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML was primarily seen in immunosuppressed patients with AIDS or certain cancers, bu...

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Detalles Bibliográficos
Autores principales: Wharton, Keith A., Quigley, Catherine, Themeles, Marian, Dunstan, Robert W., Doyle, Kathryn, Cahir-McFarland, Ellen, Wei, Jing, Buko, Alex, Reid, Carl E., Sun, Chao, Carmillo, Paul, Sur, Gargi, Carulli, John P., Mansfield, Keith G., Westmoreland, Susan V., Staugaitis, Susan M., Fox, Robert J., Meier, Werner, Goelz, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871437/
https://www.ncbi.nlm.nih.gov/pubmed/27191595
http://dx.doi.org/10.1371/journal.pone.0155897

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