BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett’s Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2

BACKGROUND: Bone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett’s esophagus (BE), a precursor of esophageal adenocarcinoma (EAC). In various cancers, BMP4 has been found to induce epithelial-mesenchymal transition (EMT) but its function in the development of EAC i...

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Detalles Bibliográficos
Autores principales: Kestens, Christine, Siersema, Peter D., Offerhaus, G. Johan A., van Baal, Jantine W. P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871520/
https://www.ncbi.nlm.nih.gov/pubmed/27191723
http://dx.doi.org/10.1371/journal.pone.0155754

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