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Identification of a Transcription Factor That Regulates Host Cell Exit and Virulence of Mycobacterium tuberculosis

The interaction of Mycobacterium tuberculosis (Mtb) with host cell death signaling pathways is characterized by an initial anti-apoptotic phase followed by a pro-necrotic phase to allow for host cell exit of the bacteria. The bacterial modulators regulating necrosis induction are poorly understood....

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Detalles Bibliográficos
Autores principales: Srinivasan, Lalitha, Gurses, Serdar A., Hurley, Benjamin E., Miller, Jessica L., Karakousis, Petros C., Briken, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871555/
https://www.ncbi.nlm.nih.gov/pubmed/27191591
http://dx.doi.org/10.1371/journal.ppat.1005652