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Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

Glucagon secretion dysregulation in diabetes fosters hyperglycemia. Recent studies report that mice lacking glucagon receptor (Gcgr(-/-)) do not develop diabetes following streptozotocin (STZ)-mediated ablation of insulin-producing β-cells. Here, we show that diabetes prevention in STZ-treated Gcgr(...

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Detalles Bibliográficos
Autores principales:	Damond, Nicolas, Thorel, Fabrizio, Moyers, Julie S, Charron, Maureen J, Vuguin, Patricia M, Powers, Alvin C, Herrera, Pedro L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871705/ https://www.ncbi.nlm.nih.gov/pubmed/27092792 http://dx.doi.org/10.7554/eLife.13828

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