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Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study

Intensive rehabilitation interventions have been shown to be efficacious in improving upper extremity function in children with unilateral spastic cerebral palsy (USCP). These interventions are based on motor learning principles and engage children in skillful movements. Improvements in upper extrem...

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Autores principales: Bleyenheuft, Yannick, Dricot, Laurence, Gilis, Nathalie, Kuo, Hsing-Ching, Grandin, Cécile, Bleyenheuft, Corinne, Gordon, Andrew M., Friel, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871716/
https://www.ncbi.nlm.nih.gov/pubmed/26183338
http://dx.doi.org/10.1016/j.ridd.2015.06.014
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author Bleyenheuft, Yannick
Dricot, Laurence
Gilis, Nathalie
Kuo, Hsing-Ching
Grandin, Cécile
Bleyenheuft, Corinne
Gordon, Andrew M.
Friel, Kathleen M.
author_facet Bleyenheuft, Yannick
Dricot, Laurence
Gilis, Nathalie
Kuo, Hsing-Ching
Grandin, Cécile
Bleyenheuft, Corinne
Gordon, Andrew M.
Friel, Kathleen M.
author_sort Bleyenheuft, Yannick
collection PubMed
description Intensive rehabilitation interventions have been shown to be efficacious in improving upper extremity function in children with unilateral spastic cerebral palsy (USCP). These interventions are based on motor learning principles and engage children in skillful movements. Improvements in upper extremity function are believed to be associated with neuroplastic changes. However, these neuroplastic changes have not been well-described in children with cerebral palsy, likely due to challenges in defining and implementing the optimal tools and tests in children. Here we documented the implementation of three different neurological assessments (diffusion tensor imaging-DTI, transcranial magnetic stimulation-TMS and functional magnetic resonance imaging-fMRI) before and after a bimanual intensive treatment (HABIT-ILE) in two children with USCP presenting differential corticospinal developmental reorganization (ipsilateral and contralateral). The aim of the study was to capture neurophysiological changes and to document the complementary relationship between these measures, the potential measurable changes and the feasibility of applying these techniques in children with USCP. Independent of cortical reorganization, both children showed increases in activation and size of the motor areas controlling the affected hand, quantified with different techniques. In addition, fMRI provided additional unexpected changes in the reward circuit while using the affected hand.
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spelling pubmed-48717162016-05-18 Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study Bleyenheuft, Yannick Dricot, Laurence Gilis, Nathalie Kuo, Hsing-Ching Grandin, Cécile Bleyenheuft, Corinne Gordon, Andrew M. Friel, Kathleen M. Res Dev Disabil Article Intensive rehabilitation interventions have been shown to be efficacious in improving upper extremity function in children with unilateral spastic cerebral palsy (USCP). These interventions are based on motor learning principles and engage children in skillful movements. Improvements in upper extremity function are believed to be associated with neuroplastic changes. However, these neuroplastic changes have not been well-described in children with cerebral palsy, likely due to challenges in defining and implementing the optimal tools and tests in children. Here we documented the implementation of three different neurological assessments (diffusion tensor imaging-DTI, transcranial magnetic stimulation-TMS and functional magnetic resonance imaging-fMRI) before and after a bimanual intensive treatment (HABIT-ILE) in two children with USCP presenting differential corticospinal developmental reorganization (ipsilateral and contralateral). The aim of the study was to capture neurophysiological changes and to document the complementary relationship between these measures, the potential measurable changes and the feasibility of applying these techniques in children with USCP. Independent of cortical reorganization, both children showed increases in activation and size of the motor areas controlling the affected hand, quantified with different techniques. In addition, fMRI provided additional unexpected changes in the reward circuit while using the affected hand. 2015-07-13 2015 /pmc/articles/PMC4871716/ /pubmed/26183338 http://dx.doi.org/10.1016/j.ridd.2015.06.014 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bleyenheuft, Yannick
Dricot, Laurence
Gilis, Nathalie
Kuo, Hsing-Ching
Grandin, Cécile
Bleyenheuft, Corinne
Gordon, Andrew M.
Friel, Kathleen M.
Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study
title Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study
title_full Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study
title_fullStr Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study
title_full_unstemmed Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study
title_short Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study
title_sort capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: a combined dti, tms and fmri pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871716/
https://www.ncbi.nlm.nih.gov/pubmed/26183338
http://dx.doi.org/10.1016/j.ridd.2015.06.014
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