Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling

OBJECTIVE: To test whether Toll-like receptor (TLR) signaling plays a key role for reduced nuclear factor B (NF-κB) activation after laquinimod treatment in the model of cuprizone-induced demyelination, oligodendrocyte apoptosis, inflammation, and axonal damage. METHODS: Ten-week-old C57BL/6J, TLR4(...

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Detalles Bibliográficos
Autores principales: Kramann, Nadine, Menken, Lena, Hayardeny, Liat, Hanisch, Uwe-Karsten, Brück, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871804/
https://www.ncbi.nlm.nih.gov/pubmed/27231712
http://dx.doi.org/10.1212/NXI.0000000000000233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871804/
https://www.ncbi.nlm.nih.gov/pubmed/27231712
http://dx.doi.org/10.1212/NXI.0000000000000233

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