Cargando…

Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations

OBJECTIVE: We undertook a systems immunology approach of the adaptive immune system in multiple sclerosis (MS), overcoming tradeoffs between scale and level of detail, in order to identify the immunologic signature of MS and the changes wrought by current immunomodulatory treatments. METHODS: We dev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dooley, James, Pauwels, Ine, Franckaert, Dean, Smets, Ide, Garcia-Perez, Josselyn E., Hilven, Kelly, Danso-Abeam, Dina, Terbeek, Joanne, Nguyen, Anh T.L., De Muynck, Louis, Decallonne, Brigitte, Dubois, Bénédicte, Liston, Adrian, Goris, An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872020/ https://www.ncbi.nlm.nih.gov/pubmed/27231713 http://dx.doi.org/10.1212/NXI.0000000000000240

Ejemplares similares

Models of Aire-Dependent Gene Regulation for Thymic Negative Selection
por: Danso-Abeam, Dina, et al.
Publicado: (2011)

Progress in Multiple Sclerosis Genetics
por: Goris, An, et al.
Publicado: (2012)

Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators
por: Lagou, Vasiliki, et al.
Publicado: (2018)

Olmsted syndrome: exploration of the immunological phenotype
por: Danso-Abeam, Dina, et al.
Publicado: (2013)

Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells
por: Smets, Ide, et al.
Publicado: (2018)

Treatment-Induced BAFF Expression and B Cell Biology in Multiple Sclerosis
por: Smets, Ide, et al.
Publicado: (2021)

Comment on “Olmsted Syndrome”
por: Gatault, Solene, et al.
Publicado: (2020)

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients
por: Smets, Ide, et al.
Publicado: (2021)

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease
por: Van Horebeek, Lies, et al.
Publicado: (2019)

CHIT1 at Diagnosis Reflects Long‐Term Multiple Sclerosis Disease Activity
por: Oldoni, Emanuela, et al.
Publicado: (2020)

miR-29a-deficiency does not modify the course of murine pancreatic acinar carcinoma
por: Dooley, James, et al.
Publicado: (2017)

The cellular composition of the human immune system is shaped by age and cohabitation
por: Carr, Edward J., et al.
Publicado: (2016)

The Long Non-coding RNA Flatr Anticipates Foxp3 Expression in Regulatory T Cells
por: Brajic, Aleksandra, et al.
Publicado: (2018)

Premature thymic involution is independent of structural plasticity of the thymic stroma
por: Franckaert, Dean, et al.
Publicado: (2015)

Effects of Vitamin D and Body Mass Index on Disease Risk and Relapse Hazard in Multiple Sclerosis: A Mendelian Randomization Study
por: Vandebergh, Marijne, et al.
Publicado: (2022)

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3(+) and Foxp3(−) T cells
por: Franckaert, Dean, et al.
Publicado: (2015)

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study
por: Vandebergh, Marijne, et al.
Publicado: (2022)

Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity
por: Cole, Jennifer E, et al.
Publicado: (2018)

Frequent somatic mosaicism in T lymphocyte subsets in individuals with and without multiple sclerosis
por: Van Horebeek, Lies, et al.
Publicado: (2022)

The Influence of Prior Hyperthyroidism on Euthyroid Graves' Ophthalmopathy
por: Termote, Karolien, et al.
Publicado: (2014)

Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
por: Bollen, Heleen, et al.
Publicado: (2021)

Presymptomatic MS or radiologically isolated syndrome (RIS) should be actively monitored and treated – NO
por: Smets, Ide
Publicado: (2023)

The Aire family expands
por: Liston, Adrian, et al.
Publicado: (2019)

A new ICB sister journal focuses on clinical and translational immunology
por: Belz, Gabrielle, et al.
Publicado: (2012)

A targeted sequencing extension for transcript genotyping in single-cell transcriptomics
por: Van Horebeek, Lies, et al.
Publicado: (2023)

Antiepileptic Drugs and Thyroid Hormone Homeostasis: Literature Review and Practical Guideline
por: Rochtus, Anne Maria, et al.
Publicado: (2021)

Attention stabilizes the shared gain of V4 populations
por: Rabinowitz, Neil C, et al.
Publicado: (2015)

Genome-wide Computational Analysis Reveals Cardiomyocyte-specific Transcriptional Cis-regulatory Motifs That Enable Efficient Cardiac Gene Therapy
por: Rincon, Melvin Y, et al.
Publicado: (2015)

Shared microbiological and immunological patterns in periodontitis and IBD: A scoping review
por: Baima, Giacomo, et al.
Publicado: (2021)

Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency
por: Van Eyck, Lien, et al.
Publicado: (2015)

Should anti-CD20 be used as an immune reconstitution therapy?
por: Smets, Ide, et al.
Publicado: (2022)

Restricted immunological and cellular pathways are shared by murine models of chronic alcohol consumption
por: Vogle, Alyx, et al.
Publicado: (2020)

The diseased kidney: aging and senescent immunology
por: Chi, Mingxuan, et al.
Publicado: (2022)

The governance of land use strategies: Institutional and social dimensions of land sparing and land sharing
por: Jiren, Tolera S., et al.
Publicado: (2017)

A Framework for Understanding the Evasion of Host Immunity by Candida Biofilms
por: Garcia-Perez, Josselyn E., et al.
Publicado: (2018)

Foundations of quantum mechanics, an empiricist approach
por: Muynck, Willem M
Publicado: (2004)

Diagnostic dilemmas in Alzheimer's disease: Room for shared decision making
por: van der Flier, Wiesje M., et al.
Publicado: (2017)

Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women
por: Antonio, L., et al.
Publicado: (2018)

Sharing Knowledge With Young and Established Students of Immunology by the Neapolitan Gulf at the Ruggero Ceppellini Advanced School
por: Colucci, Francesco
Publicado: (2020)

Genetic Variation in WNT9B Increases Relapse Hazard in Multiple Sclerosis
por: Vandebergh, Marijne, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cqoql2gtmpdkrc9luihqes7ibp