Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

RAD52 is a member of the homologous recombination (HR) pathway that is important for maintenance of genome integrity. While single RAD52 mutations show no significant phenotype in mammals, their combination with mutations in genes that cause hereditary breast cancer and ovarian cancer like BRCA1, BR...

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Detalles Bibliográficos
Autores principales: Huang, Fei, Goyal, Nadish, Sullivan, Katherine, Hanamshet, Kritika, Patel, Mikir, Mazina, Olga M., Wang, Charles X., An, W. Frank, Spoonamore, James, Metkar, Shailesh, Emmitte, Kyle A., Cocklin, Simon, Skorski, Tomasz, Mazin, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872086/
https://www.ncbi.nlm.nih.gov/pubmed/26873923
http://dx.doi.org/10.1093/nar/gkw087

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