Cargando…
More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance
Genome instability triggers cellular senescence and is a common cause of cancer. The ribosomal RNA genes (rDNA), due to their repetitive structure, form a fragile site with frequent rearrangements. To identify eukaryotic factors that connect reduced genome stability to senescence we screened 4,876 s...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872092/ https://www.ncbi.nlm.nih.gov/pubmed/26912831 http://dx.doi.org/10.1093/nar/gkw110 |