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The evolutionary pathway from a biologically inactive polypeptide sequence to a folded, active structural mimic of DNA

The protein Ocr (overcome classical restriction) from bacteriophage T7 acts as a mimic of DNA and inhibits all Type I restriction/modification (RM) enzymes. Ocr is a homodimer of 116 amino acids and adopts an elongated structure that resembles the shape of a bent 24 bp DNA molecule. Each monomer inc...

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Detalles Bibliográficos
Autores principales:	Kanwar, Nisha, Roberts, Gareth A., Cooper, Laurie P., Stephanou, Augoustinos S., Dryden, David T.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872106/ https://www.ncbi.nlm.nih.gov/pubmed/27095198 http://dx.doi.org/10.1093/nar/gkw234

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