The mutation spectrum in genomic late replication domains shapes mammalian GC content

Genome sequence compositions and epigenetic organizations are correlated extensively across multiple length scales. Replication dynamics, in particular, is highly correlated with GC content. We combine genome-wide time of replication (ToR) data, topological domains maps and detailed functional epige...

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Detalles Bibliográficos
Autores principales: Kenigsberg, Ephraim, Yehuda, Yishai, Marjavaara, Lisette, Keszthelyi, Andrea, Chabes, Andrei, Tanay, Amos, Simon, Itamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872117/
https://www.ncbi.nlm.nih.gov/pubmed/27085808
http://dx.doi.org/10.1093/nar/gkw268

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