Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase

Lupus nephritis (LN) is a potentially dangerous end organ pathology that affects upwards of 60% of lupus patients. Bruton’s tyrosine kinase (BTK) is important for B cell development, Fc receptor signaling, and macrophage polarization. In this study, we investigated the effects of a novel, highly sel...

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Detalles Bibliográficos
Autores principales: Chalmers, Samantha A., Doerner, Jessica, Bosanac, Todd, Khalil, Sara, Smith, Dustin, Harcken, Christian, Dimock, Janice, Der, Evan, Herlitz, Leal, Webb, Deborah, Seccareccia, Elise, Feng, Di, Fine, Jay S., Ramanujam, Meera, Klein, Elliott, Putterman, Chaim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872164/
https://www.ncbi.nlm.nih.gov/pubmed/27192942
http://dx.doi.org/10.1038/srep26164

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