Cargando…

A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve

AIMS: The mechanistic basis of the symptoms and signs of myocardial ischaemia in patients without obstructive coronary artery disease (CAD) and evidence of coronary microvascular dysfunction (CMD) is unclear. The aim of this study was to mechanistically test short-term late sodium current inhibition...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bairey Merz, C. Noel, Handberg, Eileen M., Shufelt, Chrisandra L., Mehta, Puja K., Minissian, Margo B., Wei, Janet, Thomson, Louise E.J., Berman, Daniel S., Shaw, Leslee J., Petersen, John W., Brown, Garrett H., Anderson, R. David, Shuster, Jonathan J., Cook-Wiens, Galen, Rogatko, André, Pepine, Carl J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Aha Fasttrack
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872284/ https://www.ncbi.nlm.nih.gov/pubmed/26614823 http://dx.doi.org/10.1093/eurheartj/ehv647

Ejemplares similares

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME(®) trial
por: Fitchett, David, et al.
Publicado: (2016)

Coronary endothelial dysfunction appears to be a manifestation of a systemic process: A report from the Women’s Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction (WISE-CVD) study
por: Jalnapurkar, Sawan, et al.
Publicado: (2021)

Typical angina is associated with greater coronary endothelial dysfunction but not abnormal vasodilatory reserve
por: AlBadri, Ahmed, et al.
Publicado: (2017)

N-Terminal pro-B-type natriuretic peptide and coronary microvascular dysfunction in women with preserved ejection fraction: A report from the Women’s Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction (WISE-CVD) study
por: Jones, Erika, et al.
Publicado: (2020)

Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy
por: Quesada, Odayme, et al.
Publicado: (2020)

Daily Activity Measured With Wearable Technology as a Novel Measurement of Treatment Effect in Patients With Coronary Microvascular Dysfunction: Substudy of a Randomized Controlled Crossover Trial
por: Birkeland, Kade, et al.
Publicado: (2017)

Temporal Trends in Angina, Myocardial Perfusion, and Left Ventricular Remodeling in Women With No Obstructive Coronary Artery Disease Over 1‐Year Follow‐Up: Results From WISE‐CVD
por: Quesada, Odayme, et al.
Publicado: (2020)

Do women with statin-related myalgias have low vitamin D levels?
por: Minissian, Margo, et al.
Publicado: (2015)

Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 × 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol
por: Gulati, Geeta, et al.
Publicado: (2016)

Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women’s Ischemic Syndrome Evaluation study (WISE)
por: Jones, Erika, et al.
Publicado: (2020)

THE IMPACT OF THE COVID-19 PANDEMIC ON A MULTI-CENTER CLINICAL - ADAPTING IN REAL-TIME TO MAINTAIN TRIAL INTEGRITY
por: Dasa, Osama, et al.
Publicado: (2021)

Cardiovascular and pregnancy outcomes in women with coronary microvascular dysfunction: a case series
por: Pacheco, Christine, et al.
Publicado: (2019)

Acetylcholine versus cold pressor testing for evaluation of coronary endothelial function
por: AlBadri, Ahmed, et al.
Publicado: (2017)

Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association
por: Levine, Glenn N., et al.
Publicado: (2017)

Predicted Versus Observed Major Adverse Cardiac Event Risk in Women With Evidence of Ischemia and No Obstructive Coronary Artery Disease: A Report From WISE (Women's Ischemia Syndrome Evaluation)
por: Sedlak, Tara, et al.
Publicado: (2020)

Angina Hospitalization Rates in Women With Signs and Symptoms of Ischemia But no Obstructive Coronary Artery Disease: A Report from the WISE (Women's Ischemia Syndrome Evaluation) Study
por: Aldiwani, Haider, et al.
Publicado: (2020)

Relationship between coronary function testing and migraine: results from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction project
por: Siak, Jessica, et al.
Publicado: (2021)

Gender-Related Differences in Chest Pain Syndromes in the Frontiers in CV Medicine Special Issue: Sex & Gender in CV Medicine
por: Mehta, Puja K., et al.
Publicado: (2021)

Ultra-high sensitivity cardiac troponin-I concentration and left ventricular structure and function in women with ischemia and no obstructive coronary artery disease
por: Quesada, Odayme, et al.
Publicado: (2022)

The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy
por: Gold, Michael R., et al.
Publicado: (2011)

RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome
por: Steg, Ph. Gabriel, et al.
Publicado: (2011)

Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker
por: Pacheco, Christine, et al.
Publicado: (2021)

Autoimmune rheumatic diseases in women with coronary microvascular dysfunction: a report from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) project
por: Chen, Melanie T., et al.
Publicado: (2023)

A meta-analysis of randomized controlled trials in pulmonary arterial hypertension
por: Galiè, Nazzareno, et al.
Publicado: (2009)

Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy
por: Tardif, Jean-Claude, et al.
Publicado: (2011)

One year follow-up of the multi-centre European PARTNER transcatheter heart valve study
por: Lefèvre, Thierry, et al.
Publicado: (2011)

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
por: Matsa, Elena, et al.
Publicado: (2011)

Dyssynchrony by speckle-tracking echocardiography and response to cardiac resynchronization therapy: results of the Speckle Tracking and Resynchronization (STAR) study
por: Tanaka, Hidekazu, et al.
Publicado: (2010)

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation
por: Hjortnaes, Jesper, et al.
Publicado: (2010)

Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter
por: Templin, Christian, et al.
Publicado: (2013)

Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial
por: Worthley, Stephen G., et al.
Publicado: (2013)

Update on ranolazine in the management of angina
por: Codolosa, J Nicolás, et al.
Publicado: (2014)

Age at Menarche and Risk of Cardiovascular Disease Outcomes: Findings From the National Heart Lung and Blood Institute‐Sponsored Women's Ischemia Syndrome Evaluation
por: Lee, Julie J., et al.
Publicado: (2019)

Inter-scan Reproducibility of Cardiovascular Magnetic Resonance Imaging-Derived Myocardial Perfusion Reserve Index in Women with no Obstructive Coronary Artery Disease
por: Al-Badri, Ahmed, et al.
Publicado: (2018)

Ranolazine for Angina in Hypertrophic Cardiomyopathy
por: Amin, Akhtar, et al.
Publicado: (2018)

SAT-LB99 Inflammation May Mediate Coronary Artery Disease in Women With Hypothalamic Hypoestrogenemia: Findings From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE)
por: Torbati, Tina, et al.
Publicado: (2020)

Fitness attenuates long-term cardiovascular outcomes in women with ischemic heart disease and metabolic syndrome
por: Quesada, Odayme, et al.
Publicado: (2023)

OR19-6 Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease
por: Bairey Merz, C Noel, et al.
Publicado: (2022)

Utility of ranolazine in chronic stable angina patients
por: Patel, Pawan D, et al.
Publicado: (2008)

Emerging clinical role of ranolazine in the management of angina
por: Vadnais, David S, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_h8n206sndt7q9a58683ituac0u