Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation

BACKGROUND: Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SAHA is a histone deacetylase inhibitor that regulates gene expression by increas...

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Detalles Bibliográficos
Autores principales: Hu, Qing-Peng, Mao, Ding-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872358/
https://www.ncbi.nlm.nih.gov/pubmed/27193049
http://dx.doi.org/10.1186/s12868-016-0264-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872358/
https://www.ncbi.nlm.nih.gov/pubmed/27193049
http://dx.doi.org/10.1186/s12868-016-0264-9

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