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Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort

Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the d...

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Autores principales: Ihara, K, Yoshida, H, Jones, P B, Hashizume, M, Suzuki, Y, Ishijima, H, Kim, H K, Suzuki, T, Hachisu, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872405/
https://www.ncbi.nlm.nih.gov/pubmed/27070410
http://dx.doi.org/10.1038/tp.2016.47
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author Ihara, K
Yoshida, H
Jones, P B
Hashizume, M
Suzuki, Y
Ishijima, H
Kim, H K
Suzuki, T
Hachisu, M
author_facet Ihara, K
Yoshida, H
Jones, P B
Hashizume, M
Suzuki, Y
Ishijima, H
Kim, H K
Suzuki, T
Hachisu, M
author_sort Ihara, K
collection PubMed
description Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the developments of MDD and other mood disorders through a case–control study nested in a cohort of 1276 women aged 75–84 years in 2008. Psychiatrists using the Structured Clinical Interview for DSM-IV identified incident cases of mood disorders at follow-up surveys in 2010 and 2012: 28 of MDDs, 39 of minor depressive disorders (minDDs) and 8 of minor depressive episodes with a history of major depressive episodes (minDEs with MDE history). A total of 106 representative non-depressed controls were also identified in the 2012 follow-up. We assayed BDNF levels in preserved sera of cases and controls at baseline and at follow-up. Serum BDNF levels at baseline in cases of MDD, minDD or minDE with MDE history were no lower than those in controls. The decrease in the serum BDNF level from baseline to follow-up was greater in cases of MDD or minDE with MDE history than in controls or cases of minDD. These results show that serum BDNF levels are not a trait marker of MDD in old women but appeared to be a state marker. The different changes in BDNF levels among diagnostic groups suggest that MDD has a pathophysiologic relation to minDE with MDE history, rather than to minDD.
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spelling pubmed-48724052016-05-26 Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort Ihara, K Yoshida, H Jones, P B Hashizume, M Suzuki, Y Ishijima, H Kim, H K Suzuki, T Hachisu, M Transl Psychiatry Original Article Serum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the developments of MDD and other mood disorders through a case–control study nested in a cohort of 1276 women aged 75–84 years in 2008. Psychiatrists using the Structured Clinical Interview for DSM-IV identified incident cases of mood disorders at follow-up surveys in 2010 and 2012: 28 of MDDs, 39 of minor depressive disorders (minDDs) and 8 of minor depressive episodes with a history of major depressive episodes (minDEs with MDE history). A total of 106 representative non-depressed controls were also identified in the 2012 follow-up. We assayed BDNF levels in preserved sera of cases and controls at baseline and at follow-up. Serum BDNF levels at baseline in cases of MDD, minDD or minDE with MDE history were no lower than those in controls. The decrease in the serum BDNF level from baseline to follow-up was greater in cases of MDD or minDE with MDE history than in controls or cases of minDD. These results show that serum BDNF levels are not a trait marker of MDD in old women but appeared to be a state marker. The different changes in BDNF levels among diagnostic groups suggest that MDD has a pathophysiologic relation to minDE with MDE history, rather than to minDD. Nature Publishing Group 2016-04 2016-04-12 /pmc/articles/PMC4872405/ /pubmed/27070410 http://dx.doi.org/10.1038/tp.2016.47 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Ihara, K
Yoshida, H
Jones, P B
Hashizume, M
Suzuki, Y
Ishijima, H
Kim, H K
Suzuki, T
Hachisu, M
Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort
title Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort
title_full Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort
title_fullStr Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort
title_full_unstemmed Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort
title_short Serum BDNF levels before and after the development of mood disorders: a case–control study in a population cohort
title_sort serum bdnf levels before and after the development of mood disorders: a case–control study in a population cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872405/
https://www.ncbi.nlm.nih.gov/pubmed/27070410
http://dx.doi.org/10.1038/tp.2016.47
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