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11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse

The identification of new and more effective treatments for alcohol abuse remains a priority. Alcohol intake activates glucocorticoids, which have a key role in alcohol's reinforcing properties. Glucocorticoid effects are modulated in part by the activity of 11β-hydroxysteroid dehydrogenases (1...

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Detalles Bibliográficos
Autores principales: Sanna, P P, Kawamura, T, Chen, J, Koob, G F, Roberts, A J, Vendruscolo, L F, Repunte-Canonigo, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872439/
https://www.ncbi.nlm.nih.gov/pubmed/26978742
http://dx.doi.org/10.1038/tp.2016.13